alpha-Pyrrolidinohexiophenone

alpha-Pyrrolidinohexiophenone
Clinical data
Routes of
administration
oral, intranasal, vaporization, intravenous, rectal, sublingual,subcutaneous
Legal status
Legal status
Identifiers
CAS Number 13415-86-6 YesY
HCl: 13415-59-3
PubChem (CID) 102107923
ChemSpider 52084419
UNII 297J9K8A4G YesY
Chemical and physical data
Formula C16H23NO
Molar mass 245.37 g·mol−1
3D model (Jmol) Interactive image

α-Pyrrolidinohexiophenone (α-PHP, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s[1] which has been reported as a novel designer drug.[2][3][4][5][6] It is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain, and is a structural isomer of pyrovalerone.[7]

Legality

The President of the Republic of Italy classified cathinone and all structurally derived analogues (including pyrovalerone analogues) as Narcotics on January 2012. [8][9]

Sweden's public health agency suggested to classify α-PHP as narcotic on June 1, 2015.[10]

As of October 2015 α-PHP is a controlled substance in China.[11]

See also

References

  1. "US Patent 3314970 - α-Pyrrolidino ketones". Ernst Seeger. Retrieved 18 June 2015.
  2. Nahoko Uchiyama; Yoshihiko Shimokawa; Maiko Kawamura; Ruri Kikura-Hanajiri; Takashi Hakamatsuka (August 2014). "Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products". Forensic Toxicology. 32 (2): 266–281. doi:10.1007/s11419-014-0238-5.
  3. Milena Majchrzak; Marcin Rojkiewicz; Rafał Celiński; Piotr Kuś; Mieczysław Sajewicz (October 2015). "Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials". Forensic Toxicology. doi:10.1007/s11419-015-0295-4.
  4. Michael Paul; Sergej Bleicher; Susanne Guber; Josef Ippisch; Aldo Polettini; Wolfgang Schultis (November 2015). "Identification of phase I and II metabolites of the new designer drug α-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)". Journal of Mass Spectrometry. 50 (11): 1305–1317. doi:10.1002/jms.3642. PMID 26505776.
  5. "α-Pyrrolidinohexanophenone". Cayman Chemical. Retrieved 17 June 2015.
  6. Janez Klavž; Maksimiljan Gorenjak; Martin Marinšek (August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018.
  7. Meltzer PC, Butler D, Deschamps JR, Madras BK (February 2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry. 49 (4): 1420–1432. doi:10.1021/jm050797a. PMC 2602954Freely accessible. PMID 16480278.
  8. "Decreto 29 dicembre 2011 (12A00013) (G.U. Serie Generale n. 3 del 4 gennaio 2012)" (PDF).
  9. "EMCDDA–Europol Joint Report on a new psychoactive substance: 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP)". European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). September 2015.
  10. "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara". Retrieved 29 June 2015.
  11. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.

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