D-161

D-161
Identifiers

IUPAC name 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol
PubChem (CID)	11545250
ChemSpider	9720029
Chemical and physical data
Formula	C₂₅H₂₇NO₂
Molar mass	373.486 g/mol
3D model (Jmol)	Interactive image
SMILES Oc2ccc(cc2)CNC(CC3)COC3C(c1ccccc1)c4ccccc4
InChI InChI=1S/C25H27NO2/c27-23-14-11-19(12-15-23)17-26-22-13-16-24(28-18-22)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-12,14-15,22,24-27H,13,16-18H2/t22-,24-/m0/s1 Key:CFCFEXCFOQWYQK-UPVQGACJSA-N
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D-161^[1] is a chemical known in research circles as a triple reuptake inhibitor. Although this compound has lent support to the inclusion of dopamine in the monoamine hypothesis of depression, D-161 has not been tested in clinical trials.

References

↑ Dutta, A.; Ghosh, B.; Biswas, S.; Reith, M. (2008). "D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action". European Journal of Pharmacology. 589 (1–3): 73–79. doi:10.1016/j.ejphar.2008.05.008. PMID 18561912.

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