CD155

PVR

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4FQP, 1DGI, 1NN8, 3EPC, 3EPD, 3EPF, 3J8F, 3J9F, 3UDW, 3URO

Identifiers

Aliases

PVR, CD155, HVED, NECL5, Necl-5, PVS, TAGE4, poliovirus receptor

External IDs

OMIM: 173850 HomoloGene: 9672 GeneCards: PVR

Genetically Related Diseases

multiple sclerosis^[1]

Gene ontology
Molecular function	• protein homodimerization activity • virus receptor activity • protein binding • receptor binding • cell adhesion molecule binding • receptor activity
Cellular component	• cytoplasm • integral component of membrane • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • cell-cell adherens junction • extracellular space • extracellular region • cell surface • extracellular exosome
Biological process	• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • cell recognition • susceptibility to natural killer cell mediated cytotoxicity • cell adhesion • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • regulation of immune response • viral entry into host cell • susceptibility to T cell mediated cytotoxicity • viral process • adherens junction organization • positive regulation of natural killer cell mediated cytotoxicity • homophilic cell adhesion via plasma membrane adhesion molecules
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5817


n/a

Ensembl


ENSG00000073008


n/a

UniProt


P15151


n/a

RefSeq (mRNA)


NM_001135768 NM_001135769 NM_001135770 NM_006505


n/a

RefSeq (protein)


NP_001129240.1 NP_001129241.1 NP_001129242.2 NP_006496.4


n/a

Location (UCSC)

Chr 19: 44.64 – 44.66 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

CD155 (cluster of differentiation 155) also known as the poliovirus receptor is a protein that in humans is encoded by the PVR gene.^[3]^[4]

Function

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily.^[5] Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells.^[6] The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses.^[6] Subsequent data has also suggested that CD155 may also be used to positively select MHC-independent T cells in the thymus.

The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication.^[3]

Structure

CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus.^[7]

Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy^[8] while a high resolution structures of the ectodomain D1 and D2 of CD155 were solved by x-ray crystallography.^[7]

References

↑ "Diseases that are genetically associated with PVR view/edit references on wikidata".
↑ "Human PubMed Reference:".
1 2 "Entrez Gene: poliovirus receptor".
↑ Koike S, Horie H, Ise I, Okitsu A, Yoshida M, Iizuka N, Takeuchi K, Takegami T, Nomoto A (October 1990). "The poliovirus receptor protein is produced both as membrane-bound and secreted forms". EMBO J. 9 (10): 3217–24. PMC 552052. PMID 2170108.
↑ Mendelsohn CL, Wimmer E, Racaniello VR (1989). "Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily". Cell. 56 (5): 855–65. doi:10.1016/0092-8674(89)90690-9. PMID 2538245.
1 2 Maier MK, Seth S, Czeloth N, et al. (2007). "The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens". European Journal of Immunology. 37 (8): 2214–25. doi:10.1002/eji.200737072. PMID 17621371.
1 2 PDB: 3epc, 3epd, 3epf, 3eow; Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG (November 2008). "Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18284–9. doi:10.1073/pnas.0807848105. PMC 2587566. PMID 19011098.
↑ PDB: 1DGI; He Y, Bowman VD, Mueller S, Bator CM, Bella J, Peng X, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG (January 2000). "Interaction of the poliovirus receptor with poliovirus". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 79–84. doi:10.1073/pnas.97.1.79. PMC 26619. PMID 10618374.

Pende D, Spaggiari GM, Marcenaro S, et al. (2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)". Blood. 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.
Pezzetti F, Palmieri A, Martinelli M, et al. (2007). "Linkage disequilibrium analysis of two genes mapping on OFC3: PVR and PVRL2". Eur. J. Hum. Genet. 15 (9): 992–4. doi:10.1038/sj.ejhg.5201868. PMID 17534374.
Stanietsky N, Simic H, Arapovic J, et al. (2009). "The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity". Proc. Natl. Acad. Sci. U.S.A. 106 (42): 17858–63. doi:10.1073/pnas.0903474106. PMC 2764881. PMID 19815499.
Tomasec P, Wang EC, Davison AJ, et al. (2005). "Downregulation of natural killer cell–activating ligand CD155 by human cytomegalovirus UL141". Nat. Immunol. 6 (2): 181–8. doi:10.1038/ni1156. PMC 2844263. PMID 15640804.
Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Pende D, Bottino C, Castriconi R, et al. (2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis". Mol. Immunol. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.
Kono T, Imai Y, Yasuda S, et al. (2008). "The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells". Int. J. Cancer. 122 (2): 317–24. doi:10.1002/ijc.23080. PMID 17893876.
Minami Y, Ikeda W, Kajita M, et al. (2007). "Necl-5/poliovirus receptor interacts in cis with integrin alphaVbeta3 and regulates its clustering and focal complex formation". J. Biol. Chem. 282 (25): 18481–96. doi:10.1074/jbc.M611330200. PMID 17446174.
Yu X, Harden K, Gonzalez LC, et al. (2009). "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells". Nat. Immunol. 10 (1): 48–57. doi:10.1038/ni.1674. PMID 19011627.
Ohka S, Igarashi H, Nagata N, et al. (2007). "Establishment of a Poliovirus Oral Infection System in Human Poliovirus Receptor-Expressing Transgenic Mice That Are Deficient in Alpha/Beta Interferon Receptor". J. Virol. 81 (15): 7902–12. doi:10.1128/JVI.02675-06. PMC 1951287. PMID 17507470.
Zhang P, Mueller S, Morais MC, et al. (2008). "Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18284–9. doi:10.1073/pnas.0807848105. PMC 2587566. PMID 19011098.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Carlsten M, Norell H, Bryceson YT, et al. (2009). "Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells". J. Immunol. 183 (8): 4921–30. doi:10.4049/jimmunol.0901226. PMID 19801517.
Kindberg E, Ax C, Fiore L, Svensson L (2009). "Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis". J. Med. Virol. 81 (5): 933–6. doi:10.1002/jmv.21444. PMID 19319949.
Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process". J. Biol. Chem. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.
Meyer D, Seth S, Albrecht J, et al. (2009). "CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains". J. Biol. Chem. 284 (4): 2235–44. doi:10.1074/jbc.M807698200. PMID 19056733.
Pende D, Castriconi R, Romagnani P, et al. (2006). "Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction". Blood. 107 (5): 2030–6. doi:10.1182/blood-2005-07-2696. PMID 16304049.
Fujito T, Ikeda W, Kakunaga S, et al. (2005). "Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3". J. Cell Biol. 171 (1): 165–73. doi:10.1083/jcb.200501090. PMC 2171219. PMID 16216929.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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CD155

Function

Structure

See also

References

Further reading