LILRA2

LILRA2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases LILRA2, CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2
External IDs HomoloGene: 68534 GeneCards: LILRA2
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

11027

n/a

Ensembl

n/a

n/a

UniProt

Q8N149

n/a

RefSeq (mRNA)

NM_001130917
NM_001290270
NM_001290271
NM_006866

n/a

RefSeq (protein)

NP_006857.2

n/a

Location (UCSC) Chr 19: 54.57 – 54.59 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.[2][3][4]

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][4]

Function

LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[5]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
  3. ↑ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. PMID 9548455.
  4. 1 2 "Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2".
  5. ↑ Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H (Apr 2016). "LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins". Nature Microbiology. 1 (6): 16054. doi:10.1038/NMICROBIOL.2016.54.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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