Uterotonic
A uterotonic, also known as ecbolic, is an agent used to induce contraction or greater tonicity of the uterus. Uterotonics are used both to induce labor, and to reduce postpartum hemorrhage.
Some uterotonics act as analogues of oxytocin. An oxytocinergic, or oxytocic, means "having to do with oxytocin (OXT)". The oxytocin receptor (OXTR) is the binding and activation site of oxytocin.
Some agents may act as indirect oxytocinergics:
- 5-HT1A Receptor (5-HT1AR): A protein responsible for inducing the secretion of oxytocin
- Serotonergic: A drug which acts upon serotonin and 5-HT1AR, resulting in oxytocin release (e.g., MDMA ("Ecstasy")
- Ergoline uterotonics include methylergonovine, ergometrine, and acetergamine
- Polypeptides include carbetocin and cargutocin
- Cloquinozine had been described as a oxytocic agent.[1]
- Epostane is another example of a drug described as a contraceptive, oxytocic agent.[2]
- U-69,593 inhibits the peripheral, though not central secretion of oxytocin and vasopressin in rats.
- Prostaglandins
- Dinoprost
- Alprostadil
- Prostaglandin F2, prostaglandin E1, carboprost[3]
- Fenprostalene in cattle.[4] This compound resembles Enprostil in structure and is a long-acting analogue of PGF2α.
- Meteneprost
- Analogs of oxytocin
- Urofollitropin is an analog of oxytocin possessing higher activity
- Carbetocin
- Demoxytocin
- (Thiazolidine-4-carboxylic acid)-oxytocin
- Conversely, a tocolytic acts to oppose uterine contractility. These agents may be oxytocinergic in mechanism. For example, atosiban works in this way.
See also
References
- ↑ Nagashima, Renpei; Takano, Noboru; Tamura, Masaaki; Shioya, Akitoshi (1966). "PHARMACOLOGICAL PROPERTIES OF 3-(p-CHLOROBENZYL) QUINOLIZIDINE TARTARATE (QB-1), A NEW OXYTOCIC". The Japanese Journal of Pharmacology. 16 (4): 353–367. doi:10.1254/jjp.16.353. ISSN 0021-5198.
- ↑ Elks, J.; Ganellin, C. R. (1990). "Dictionary of Drugs". doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2087-7.
- ↑ https://www.openanesthesia.org/aba_oxytocic_drugs_-_indications/
- ↑ Garcia-Villar, R.; Marnet, P.G.; Laurentie, M.P.; Toutain, P.L. (1987). "Fenprostalene in cattle: Evaluation of oxytocic effects in ovariectomized cows and abortion potential in a 100-day pregnant cow". Theriogenology. 28 (4): 467–480. doi:10.1016/0093-691X(87)90251-2. ISSN 0093-691X.
External links
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Look up Oxytocinergic in Wiktionary, the free dictionary. |
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"Oxytocics". New International Encyclopedia. 1905.
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