TFAM

TFAM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3, transcription factor A, mitochondrial
External IDs MGI: 107810 HomoloGene: 31139 GeneCards: TFAM
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

7019

21780

Ensembl

ENSG00000108064

ENSMUSG00000003923

UniProt

Q00059

P40630

RefSeq (mRNA)

NM_001270782
NM_003201
NM_012251

NM_009360

RefSeq (protein)

NP_001257711.1
NP_003192.1

NP_033386.1

Location (UCSC) Chr 10: 58.39 – 58.4 Mb Chr 10: 71.23 – 71.24 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene.[3][4]

Function

This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. TFAM bends mitochondrial promoter DNA to aid transcription of the mitochondrial genome. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.[4]

Interactions

TFAM has been shown to interact with TFB1M.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Tiranti V, Rossi E, Ruiz-Carrillo A, Rossi G, Rocchi M, DiDonato S, Zuffardi O, Zeviani M (Jul 1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis". Genomics. 25 (2): 559–64. doi:10.1016/0888-7543(95)80058-T. PMID 7789991.
  4. 1 2 "Entrez Gene: TFAM transcription factor A, mitochondrial".
  5. McCulloch V, Shadel GS (Aug 2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325Freely accessible. PMID 12897151.

Further reading


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