Small nucleolar RNA snR54

Small nucleolar RNA snR54

Predicted secondary structure and sequence conservation of snosnR54
Identifiers
Symbol snosnR54
Rfam RF00473
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snR54 is a non-coding RNA that is a member of the C/D class of snoRNA which contain the C box motif (UGAUGA) and D box motif (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. This snoRNA was first identified by a computational screen followed by experimental verification.[1] This RNA guides the 2'-O-methylation of 18S rRNA. In yeast this snoRNA is found to reside in an intron of the IMD4 gene.

Species distribution

This snoRNA has been identified in both yeasts and Drosophila melanogaster.[2]

References

  1. Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
  2. Lowe, T. M.; Eddy, S. R. (February 1999). "A Computational Screen for Methylation Guide snoRNAs in Yeast". Science. 283 (5405): 1168–1171. Bibcode:1999Sci...283.1168L. doi:10.1126/science.283.5405.1168. PMID 10024243.
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