Small nucleolar RNA MBII-202

Small nucleolar RNA MBII-202

Predicted secondary structure and sequence conservation of snoMBII-202
Identifiers
Symbol snoMBII-202
Rfam RF00324
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

Small nucleolar RNA MBII-202 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA MBII-202 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

snoRNA MBII-202 was originally cloned from mouse brain tissues.[3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523.
  2. ↑ Kiss, Tamás (2002). "Small Nucleolar RNAs". Cell. 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
  3. ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495Freely accessible. PMID 11387227.


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