SMC6

SMC6
Identifiers
Aliases SMC6, SMC-6, SMC6L1, hstructural maintenance of chromosomes 6
External IDs MGI: 1914491 HomoloGene: 41575 GeneCards: SMC6
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

79677

67241

Ensembl

ENSG00000163029

ENSMUSG00000020608

UniProt

Q96SB8

Q924W5

RefSeq (mRNA)

NM_001142286
NM_024624

NM_025695
NM_001324476

RefSeq (protein)

NP_001135758.1
NP_078900.1

NP_079971.2
NP_001311405.1

Location (UCSC) Chr 2: 17.66 – 17.8 Mb Chr 12: 11.27 – 11.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.[3][4]

It is involved in the Alternative lengthening of telomeres cancer mechanism.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072Freely accessible. PMID 11230166.
  4. "Entrez Gene: SMC6 structural maintenance of chromosomes 6".
  5. Potts PR, Yu H (2007). "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins.". Nat. Struct. Mol. Biol. 14 (7): 581–90. doi:10.1038/nsmb1259. PMID 17589526.

Further reading


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