Ramanujan Hegde
| Ramanujan S. Hegde | |
|---|---|
| Born | Ramanujan Shankar Hegde |
| Fields | Biochemistry |
| Institutions | |
| Alma mater | |
| Thesis | The regulation of protein translocation at the endoplasmic reticulum (1998) |
| Doctoral advisor | Vishwanath R. Lingappa[2] |
| Notable awards | |
|
Website | |
Ramanujan Shankar Hegde FRS[3] is a Group Leader in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).[4]
Education
Hegde was educated at the University of Chicago[1] and the University of California, San Francisco where he was awarded an MD in 1999 and PhD in 1998 for research on protein targeting and translocation at the endoplasmic reticulum supervised by Vishwanath R. Lingappa.[1][2]
Research
Hegde's research investigates how proteins are localised correctly inside cells, and how errors during protein maturation are recognised and disposed. These processes are important because the accumulation of abnormal proteins is disruptive to cell function, and underlies numerous diseases.[3]
His laboratory have discovered a widely conserved protein targeting pathway[5] needed by a subset of proteins to reach their correct membrane-embedded destination. Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion. Hegde’s work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration, and that cells have specialized pathways to identify these wayward proteins and target them for destruction.[3]
As of 2016, according to Google Scholar his most cited research include papers published in Science[6] Nature,[7] and Cell.[5] His research has been funded by the Medical Research Council.[8]
Awards and honours
Hegde was awarded the R.R. Bensley award in Cell Biology in 2008 and elected a member of the European Molecular Biology Organisation (EMBO) in 2013.[3] He was also elected a Fellow of the Royal Society (FRS) in 2016.[3]
References
- 1 2 3 Sedwick, Caitlin (2010). "Ramanujan Hegde: The prion puzzle and protein translocation". The Journal of Cell Biology. 191 (7): 1222–1223. doi:10.1083/jcb.1917pi.
- 1 2 Hegde, Ramanujan Shankar (1998). The regulation of protein translocation at the endoplasmic reticulum (PhD thesis). University of California, San Francisco. OCLC 50795524.
- 1 2 3 4 5 6 "Dr Ramanujan Hegde FRS". London: The Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
- ↑ "Ramanujan Hegde MRC Laboratory of Molecular Biology: Membrane protein biosynthesis and quality control". Cambridge: cam.ac.uk. Archived from the original on 2016-04-13.
- 1 2 Stefanovic, Sandra; Hegde, Ramanujan S. (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128: 1147–1159. doi:10.1016/j.cell.2007.01.036. PMID 17382883.
- ↑ Hegde, R. S. (1998). "A Transmembrane Form of the Prion Protein in Neurodegenerative Disease". Science. 279 (5352): 827–834. doi:10.1126/science.279.5352.827. PMID 9452375.
- ↑ Hegde, Ramanujan S.; Tremblay, Patrick; Groth, Darlene; DeArmond, Stephen J.; Prusiner, Stanley B.; Lingappa, Vishwanath R. (1999). "Transmissible and genetic prion diseases share a common pathway of neurodegeneration". Nature. 402 (6763): 822–826. doi:10.1038/45574. PMID 10617204.
- ↑ "UK Government Grants awarded to Ramanujan Hegde". Swindon: Research Councils UK. Archived from the original on 2016-05-04.