Ian A. Graham

For other people called Ian Graham, see Ian Graham (disambiguation).
Ian A. Graham
FRS
Institutions
Alma mater
Thesis Structure and function of the cucumber malate synthase gene and expression during plant development (1989)
Doctoral advisor
Website
www.york.ac.uk/biology/research/plant-biology/ian-a-graham/

Ian Alexander Graham FRS[1] is a Professor of Biochemical Genetics in the Centre for Novel Agricultural Products (CNAP) at the University of York where he is also Head of the Department of Biology.[2][3]

Education

Graham was educated at Queen's University Belfast where he was awarded a Bachelor of Science degree in Botany and Genetics in 1986.[2] He completed his PhD at the University of Edinburgh in 1989 on the structure and function of the malate synthase gene in cucumber supervised by Steven M. Smith and Chris J. Leaver.[4][5]

Career

From 1990 to 1993 he was a postdoctoral researcher in the Department of Plant Sciences at the University of Oxford. He was appointed a Lecturer in the division of Biochemistry and Molecular Biology at University of Glasgow from 1994 to 1999. During 1994, he was a SERC/NATO funded research scientist in Department of Plant Biology at Stanford University. He has been Chair of Biochemical Genetics at York since 1999.

Research

Graham’s interests include how plants make and breakdown various metabolites, how these processes are controlled and how they impact on plant growth. He has used biochemical genetics to dissect the main metabolic pathways controlling oil mobilisation in Arabidopsis[6] seed and provided new insight into how a lipid based signal controls seed germination.[7][8] He has used similar approaches to investigate the synthesis of bioactive compounds in two of the world’s major medicinal plants. This has led to new understanding of how genome rearrangement has shaped the evolution of plant metabolism. The discovery of a 10 gene cluster responsible for the production of the anti-cancer compound noscapine in opium poppy provided the tools for molecular breeding of new commercial varieties. The discovery of a novel Cytochrome P450 – oxidoreductase gene fusion described the last unknown step in synthesis of morphine and codeine. Characterisation and genetic mapping of traits responsible for production of artemisinin in Artemisia annua has enabled development of F1 hybrid seed that can deliver a robust source of this vital antimalarial medication for the developing countries.[9]

Awards and honours

Graham was elected a Fellow of the Royal Society (FRS) in 2016.[1]

References

  1. 1 2 "Professor Ian Graham FRS". London: Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
  2. 1 2 "Professor Ian A Graham: Head of Department and Weston Chair of Biochemical Genetics". York: york.ac.uk. Archived from the original on 2015-04-03.
  3. ↑ Ian A. Graham's publications indexed by Google Scholar
  4. ↑ Graham, Ian Alexander (1989). Structure and function of the cucumber malate synthase gene and expression during plant development (PhD thesis). University of Edinburgh.
  5. ↑ Graham, Ian A.; Smith, Laura M.; Brown, John W. S.; Leaver, Christopher J.; Smith, Steven M. (1989). "The malate synthase gene of cucumber". Plant Molecular Biology. 13 (6): 673–684. doi:10.1007/BF00016022. PMID 2491683.
  6. ↑ Graham, Ian A. (2008). "Seed Storage Oil Mobilization". Annual Review of Plant Biology. 59 (1): 115–142. doi:10.1146/annurev.arplant.59.032607.092938.
  7. ↑ Li-Beisson, Yonghua; Shorrosh, Basil; Beisson, Fred; Andersson, Mats X.; Arondel, Vincent; Bates, Philip D.; Baud, Sébastien; Bird, David; DeBono, Allan; Durrett, Timothy P.; Franke, Rochus B.; Graham, Ian A.; Katayama, Kenta; Kelly, Amélie A.; Larson, Tony; Markham, Jonathan E.; Miquel, Martine; Molina, Isabel; Nishida, Ikuo; Rowland, Owen; Samuels, Lacey; Schmid, Katherine M.; Wada, Hajime; Welti, Ruth; Xu, Changcheng; Zallot, Rémi; Ohlrogge, John (2013). "Acyl-Lipid Metabolism". The Arabidopsis Book. 11: e0161. doi:10.1199/tab.0161.
  8. ↑ Eastmond, Peter J.; van Dijken, Anja J. H.; Spielman, Melissa; Kerr, Aimie; Tissier, Alain F.; Dickinson, Hugh G.; Jones, Jonathan D. G.; Smeekens, Sjef C.; Graham, Ian A. (2002). "Trehalose-6-phosphate synthase 1, which catalyses the first step in trehalose synthesis, is essential forArabidopsisembryo maturation". The Plant Journal. 29 (2): 225–235. doi:10.1046/j.1365-313x.2002.01220.x.
  9. ↑ Graham, I. A.; Besser, K.; Blumer, S.; Branigan, C. A.; Czechowski, T.; Elias, L.; Guterman, I.; Harvey, D.; Isaac, P. G.; Khan, A. M.; Larson, T. R.; Li, Y.; Pawson, T.; Penfield, T.; Rae, A. M.; Rathbone, D. A.; Reid, S.; Ross, J.; Smallwood, M. F.; Segura, V.; Townsend, T.; Vyas, D.; Winzer, T.; Bowles, D. (2010). "The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin". Science. 327 (5963): 328–331. doi:10.1126/science.1182612. PMID 20075252.
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