OSTbeta

SLC51B
Identifiers
Aliases SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit
External IDs MGI: 3582052 HomoloGene: 18721 GeneCards: SLC51B
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

123264

330962

Ensembl

ENSG00000186198

ENSMUSG00000053862

UniProt

Q86UW2

Q80WK2

RefSeq (mRNA)

NM_178859

NM_178933

RefSeq (protein)

NP_849190.2

NP_849264.1

Location (UCSC) Chr 15: 65.05 – 65.05 Mb Chr 9: 65.41 – 65.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[3][4]

Function

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[4][5] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[5] The heterodimer furthermore is essential for intestinal bile acid transport.[6]

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[4]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. "Entrez Gene: OSTbeta organic solute transporter beta".
  4. 1 2 3 Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
  5. 1 2 Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727Freely accessible. PMID 15563450.
  6. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. doi:10.1073/pnas.0712328105. PMC 2268840Freely accessible. PMID 18292224.

Further reading


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