OSTalpha

SLC51A
Identifiers
Aliases SLC51A, OSTA, OSTalpha, solute carrier family 51 alpha subunit
External IDs MGI: 2146634 HomoloGene: 44941 GeneCards: SLC51A
Orthologs
Species Human Mouse
Entrez

200931

106407

Ensembl

ENSG00000163959

ENSMUSG00000035699

UniProt

Q86UW1

Q8R000

RefSeq (mRNA)

NM_152672

NM_145932

RefSeq (protein)

NP_689885.4

NP_666044.1

Location (UCSC) Chr 3: 196.21 – 196.24 Mb Chr 16: 32.48 – 32.49 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.[3][4]

Function

OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[4][5] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[5] The heterodimer furthermore is essential for intestinal bile acid transport.[6]

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[4]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. "Entrez Gene: OSTalpha organic solute transporter alpha".
  4. 1 2 3 Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.
  5. 1 2 Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727Freely accessible. PMID 15563450.
  6. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. doi:10.1073/pnas.0712328105. PMC 2268840Freely accessible. PMID 18292224.

Further reading


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