Fibroblast growth factor receptor 4

FGFR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QQ5, 4QQC, 4QQJ, 4QQT, 4QRC, 4R6V, 4TYE, 4TYG, 4TYI, 4TYJ, 4UXQ, 4XCU
Identifiers
Aliases	FGFR4, CD334, JTK2, TKF, fibroblast growth factor receptor 4
External IDs	MGI: 95525 HomoloGene: 20461 GeneCards: FGFR4
Targeted by Drug
nintedanib[1]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • heparin binding • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • fibroblast growth factor binding • fibroblast growth factor-activated receptor activity • ATP binding • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • cytoplasm • integral component of membrane • endosome • Golgi apparatus • membrane • cell-cell junction • plasma membrane • integral component of plasma membrane • transport vesicle • nucleoplasm • extracellular region • endoplasmic reticulum Biological process • regulation of cholesterol homeostasis • glucose homeostasis • phosphorylation • phosphate ion homeostasis • response to bile acid • regulation of extracellular matrix disassembly • MAPK cascade • regulation of bile acid biosynthetic process • fibroblast growth factor receptor signaling pathway • regulation of lipid metabolic process • protein phosphorylation • positive regulation of gene expression • positive regulation of cell proliferation • positive regulation of DNA biosynthetic process • positive regulation of ERK1 and ERK2 cascade • positive regulation of proteolysis • protein autophosphorylation • peptidyl-tyrosine phosphorylation • cell migration • phosphatidylinositol-mediated signaling • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • positive regulation of catalytic activity • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2264	14186
Ensembl	ENSG00000160867	ENSMUSG00000005320
UniProt	P22455	Q03142
RefSeq (mRNA)	NM_001291980 NM_002011 NM_022963 NM_213647	NM_008011
RefSeq (protein)	NP_001278909.1 NP_002002.3 NP_075252.2 NP_998812.1	NP_032037.2
Location (UCSC)	Chr 5: 177.09 – 177.1 Mb	Chr 13: 55.15 – 55.17 Mb
PubMed search	[2]	[3]
Wikidata

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334).

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.^[4]

Interactions

Fibroblast growth factor receptor 4 has been shown to interact with FGF1.^[5][6]

References

Further reading

External links

• FGFR4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.