E2 (HCV)

HCV genome

E2 is a viral structural protein found in the hepatitis C virus.[1][2] It is present on the viral membrane and functions as a host receptor binding protein, mediating entry into host cells. Therefore, it is a key target for the design of entry inhibitors and vaccine immunogens.[3]

References

  1. ↑ Garcia JE, Puentes A, Súarez J, López R, Vera R, Rodríguez LE, Ocampo M, Curtidor H, Guzman F, Urquiza M, Patarroyo ME (2002). "Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells". Journal of Hepatology. 36 (2): 254–62. doi:10.1016/S0168-8278(01)00262-8. PMID 11830338.
  2. ↑ Bartosch B, Dubuisson J, Cosset FL (2003). "Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes". The Journal of Experimental Medicine. 197 (5): 633–42. doi:10.1084/jem.20021756. PMC 2193821Freely accessible.
  3. ↑ Kong L, Giang E, Nieusma T, Kadam RU, Cogburn KE, Hua Y, Dai X, Stanfield RL, Burton DR, Ward AB, Wilson IA, Law M (2013). "Hepatitis C virus E2 envelope glycoprotein core structure". Science. 342 (6162): 1090–4. doi:10.1126/science.1243876. PMC 3954638Freely accessible. PMID 24288331.


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