Chanoclavine-I dehydrogenase

Chanoclavine-I dehydrogenase
Identifiers
EC number 1.1.1.332
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Chanoclavine-I dehydrogenase (EC 1.1.1.332, easD (gene), fgaDH (gene)) is an enzyme with systematic name chanoclavine-I:NAD+ oxidoreductase.[1][2] This enzyme catalises the following chemical reaction

chanoclavine-I + NAD+ chanoclavine-I aldehyde + NADH + H+

This enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.

References

  1. Wallwey, C.; Matuschek, M.; Li, S.M. (2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH". Arch. Microbiol. 192 (2): 127–134. doi:10.1007/s00203-009-0536-1. PMID 20039019.
  2. Wallwey, C.; Heddergott, C.; Xie, X.; Brakhage, A.A.; Li, S.M. (2012). "Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae". Microbiology. 158 (Pt 6): 1634–1644. doi:10.1099/mic.0.056796-0. PMID 22403186.

External links

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