DNA damage-inducible transcript 3

DDIT3
Identifiers
Aliases DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3, DNA damage inducible transcript 3
External IDs MGI: 109247 HomoloGene: 3012 GeneCards: DDIT3
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

1649

13198

Ensembl

ENSG00000175197

ENSMUSG00000025408

UniProt

P35638

P35639

RefSeq (mRNA)

NM_001290183
NM_007837

RefSeq (protein)

NP_001181982.1
NP_001181983.1
NP_001181984.1
NP_001181986.1
NP_004074.2

NP_001277112.1
NP_031863.3

Location (UCSC) Chr 12: 57.52 – 57.52 Mb Chr 10: 127.29 – 127.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a transcription factor that is encoded by the DDIT3 gene.[3][4]

Interactions

DNA damage-inducible transcript 3 has been shown to interact with [proteins]:

Clinical significance

Mutations or fusions of CHOP (e.g. with FUS to form FUS-CHOP) can cause Myxoid liposarcoma.[11]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (March 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol. 11 (2): 1009–16. PMC 359769Freely accessible. PMID 1990262.
  4. "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3".
  5. Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. 16 (3): 1157–68. doi:10.1128/MCB.16.3.1157. PMC 231098Freely accessible. PMID 8622660.
  6. 1 2 3 Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780Freely accessible. PMID 10523647.
  7. Hattori T, Ohoka N, Hayashi H, Onozaki K (April 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. 541 (1-3): 33–9. doi:10.1016/s0014-5793(03)00283-7. PMID 12706815.
  8. Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ (June 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. PMID 8662954.
  9. Ubeda M, Habener JF (October 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation". J. Biol. Chem. 278 (42): 40514–20. doi:10.1074/jbc.M306404200. PMID 12876286.
  10. Cui K, Coutts M, Stahl J, Sytkowski AJ (March 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. 275 (11): 7591–6. doi:10.1074/jbc.275.11.7591. PMID 10713066.
  11. Panagopoulos I, Höglund M, Mertens F, et al. (1996). "Fusion of the EWS and CHOP genes in myxoid liposarcoma". Oncogene. 12 (3): 489–94. PMID 8637704.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 9/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.