WWTR1

WWTR1
Identifiers
Aliases	WWTR1, TAZ, WW domain containing transcription regulator 1
External IDs	MGI: 1917649 HomoloGene: 9159 GeneCards: WWTR1
Genetically Related Diseases
pre-eclampsia[1]
Gene ontology Molecular function • protein homodimerization activity • transcription corepressor activity • transcription coactivator activity • protein binding Cellular component • cytoplasm • cytosol • transcription factor complex • nucleoplasm • nucleus Biological process • negative regulation of protein phosphorylation • cilium morphogenesis • regulation of metanephric nephron tubule epithelial cell differentiation • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • negative regulation of protein kinase activity • multicellular organism growth • regulation of canonical Wnt signaling pathway • glomerulus development • negative regulation of transcription from RNA polymerase II promoter • hippo signaling • positive regulation of epithelial to mesenchymal transition • regulation of SMAD protein import into nucleus • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • mesenchymal cell differentiation • stem cell division • protein ubiquitination • osteoblast differentiation • kidney morphogenesis • positive regulation of cell proliferation • negative regulation of catenin import into nucleus • transcription initiation from RNA polymerase II promoter • negative regulation of canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25937	97064
Ensembl	ENSG00000018408	ENSMUSG00000027803
UniProt	Q9GZV5	Q9EPK5
RefSeq (mRNA)	NM_001168278 NM_001168280 NM_015472	NM_001168281 NM_133784
RefSeq (protein)	NP_001161750.1 NP_001161752.1 NP_056287.1	NP_001161753.1 NP_598545.2
Location (UCSC)	Chr 3: 149.52 – 149.74 Mb	Chr 3: 57.46 – 57.58 Mb
PubMed search	[2]	[3]
Wikidata

WW domain-containing transcription regulator protein 1 is a protein that in humans is encoded by the WWTR1 gene.^[4][5][6]

Function

WWTR1 It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/LATS2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADs and has a key role in coupling them to the transcriptional machinery such as the mediator complex.

Using the human SHSY5Y cell line as a model of neuronal differentiation, human FAT1 was shown to regulate the nucleocytoplasmic relocation of WWTR1/TAZ and enhanced transcription of the Hippo target gene CTGF. The same study also showed FAT1 was able to regulate TGF-beta signalling ^[7]

References

Further reading