Very-long-chain enoyl-CoA reductase
| Very-long-chain enoyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.93 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Very-long-chain enoyl-CoA reductase (EC 1.3.1.93, TSC13 (gene name), CER10 (gene)) is an enzyme with systematic name very-long-chain acyl-CoA:NADP+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- a very-long-chain acyl-CoA + NADP+ a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA.
References
- ↑ Kohlwein, S.D.; Eder, S.; Oh, C.S.; Martin, C.E.; Gable, K.; Bacikova, D.; Dunn, T. (2001). "Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae". Mol. Cell. Biol. 21 (1): 109–125. doi:10.1128/MCB.21.1.109-125.2001. PMC 88785
. PMID 11113186. - ↑ Gable, K.; Garton, S.; Napier, J.A.; Dunn, T.M. (2004). "Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system". J. Exp. Bot. 55 (396): 543–545. doi:10.1093/jxb/erh061. PMID 14673020.
- ↑ Kvam, E.; Gable, K.; Dunn, T.M.; Goldfarb, D.S. (2005). "Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles". Mol. Biol. Cell. 16 (9): 3987–3998. doi:10.1091/mbc.E05-04-0290. PMC 1196313. PMID 15958487.
- ↑ Zheng, H.; Rowland, O.; Kunst, L. (2005). "Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis". Plant Cell. 17 (5): 1467–1481. doi:10.1105/tpc.104.030155. PMC 1091768. PMID 15829606.
External links
- Very-long-chain enoyl-CoA reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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