Verubecestat

Verubecestat
Clinical data
ATC code None
Legal status
Legal status
  • Investigational
Identifiers
Synonyms MK-8931
CAS Number 1286770-55-5
PubChem (CID) 51352361
ChemSpider 31399364
UNII J1I0P6WT7T
KEGG D10739
Chemical and physical data
Formula C17H17F2N5O3S
Molar mass 409.41 g·mol−1
3D model (Jmol) Interactive image

Verubecestat (MK-8931) is an experimental drug for the treatment of Alzheimer's disease.[1] It is an inhibitor of beta-secretase 1 (BACE1).[2][3]

References

  1. Simon Makin (November 2, 2016). "New Alzheimer's Drug Clears Milestone in Human Clinical Trial". Scientific American.
  2. Forman, Mark; Kleijn, Huub-Jan; Dockendorf, Marissa; Palcza, John; Tseng, Jack; Canales, Christina; Egan, Michael; Kennedy, Matthew; Laterza, Omar; Ma, Lei; Scott, Jack; Tanen, Michael; Apter, Jeffrey; Backonja, Miroslav; Ereshefsky, Larry; Gevorkyan, Hakop; Jhee, Stanford; Rynders, Rebecca; Zari, Arian; Bryan, Ellie; Wagner, John; Troyer, Matthew; Stone, Julie (2013). "The novel BACE inhibitor MK-8931 dramatically lowers CSF beta-amyloid in patients with mild-to-moderate Alzheimer's disease". Alzheimer's & Dementia. 9 (4): P139. doi:10.1016/j.jalz.2013.04.083.
  3. Yan, Riqiang; Vassar, Robert (2014). "Targeting the β secretase BACE1 for Alzheimer's disease therapy". The Lancet Neurology. 13 (3): 319. doi:10.1016/S1474-4422(13)70276-X. PMID 24556009.
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