Vera Danchakoff

Vera Danchakoff, professor at Moscow University, 1908

Vera Mikhaĭlovna Danchakoff^{[note 1]} (born 1879, last publication 1950) was a Russian anatomist, cell biologist and embryologist. In 1908 she was the first woman in Russia to be appointed as a professor and she became a pioneer in stem cell research. She emigrated to the United States in 1915 where she was a leading exponent of the idea that all types of blood cell develop from a single type of cell. She has sometimes been called "the mother of stem cells". She later returned to Europe to continue with her research.

Early personal life

Vera Danchakoff – beginning of twentieth century

Danchakoff was born in St Petersburg and studied medicine there producing her thesis in 1906.^[1][2]

She married and her daughter, born in 1902 in Zurich, was Vera Evgenevna who went on to study at Columbia University and to marry Mikhail Lavrentyev, the mathematician.^[3][4][5][6] In 1915 Danchakoff emigrated to the United States where she was politically active, writing as the New York correspondent of the Moscow newspaper Utro Rossi (Russian Morning) and by helping the American Relief Administration with publicising the difficulties of Soviet scientists in working in Russia during the Great War, the Bolshevik Revolution and afterwards.^[1]

At the time there was a strong Russian émigré community in New York and, with her husband, Danchakoff hosted lavish gatherings of friends. She was a talented pianist and she took part in the musical evenings of Juan and Olga Codina, who were professional singers. She used to look after their daughter Lina when her parents were away on their extended tours – Lina later was to marry Serge Prokofiev.^[1]

Scientific career

In 1908 Danchakoff became an assistant professor at Moscow University – the first woman to become a professor in Russia.^[6][7] In 1915 she emigrated to the United States where she first worked at the Rockefeller Institute for Medical Research in New York City. Then at the Columbia University College of Physicians and Surgeons, led by Thomas Hunt Morgan, she was "instructor in anatomy" at a time when women were first being allowed admittance as students.^[1][8] In a 1916 lecture she said

"... the erythrocytes, the small lymphocytes, the different leucocytes, the wandering cells of the connective tissue, the mast cells, and the plasma cells - all these cells are different cell units, morphologically as well as physiologically but in the early embryonic stages they all had a common mother cell, and this mother cell is preserved in the adult organism and becomes the source of differentiation and regeneration and most probably also the source of pathological proliferation."

— Vera Danchakoff, Danchakoff, Vera (1916). "Origin of blood cells. Development of the haematopoitic organs and regeneration of the blood cells from the standpoint of the monophyletic school.". Anatomical Record. 10: 397–414. ^[9]

In his 2001 keynote address to the Acute Leukemia Forum Marshall Lichtman described her presentation as an "extraordinary lecture" and considered that "The rest of the century has been spent filling in the details of [her] experimental insights!".^[10] It has been claimed that a paper of Danchakoff's is the first publication to use the term "stem cell", for example "These stem cells develop on the one hand into the small lymphocytes, and on the other hand into granulocytoblasts, and further into granulocytes".^[11] It has now been confirmed that hematopoietic stem cells give rise to all other blood cells.^[12]

For these reasons Danchakoff has sometimes been called the "mother of stem cells".^[6][13] However, in terms of the actual terminology, in 1909 Alexander A. Maximow wrote in German of "Stammzelle" for the same concept in his paper "The lymphocyte as a stem cell, common to different blood elements in embryonic development and during the post-fetal life of mammals" (English translation^[14]).^[15]

Photographs published by Danchakoff in American Journal of Anatomy (1916). Left: suspension of spleen cells applied to the allantoid membrane of a chick embryo. Right: the spleen of the same chick embryo after 17 days. Note the specific induction of growth of the spleen.^[16]

In 1916 Danchakoff and James Bumgardner Murphy independently reported on a surprising discovery concerning the chick embryo – one that turned out to be of great importance. When the embryo was injected with adult lymphocytes the spleen greatly enlarged. With other types of cell this did not occur. Murphy's and Danchakoff's explanations for the effect were wrong but much later these observations led to an understanding of lymphocyte migration and graft-versus-host disease.^[13]

In 1934 Danchakoff left Columbia and until 1937 worked in the Department of Histology and Embryology at the Lithuanian University of Health Sciences.^[17] In 1938 she conducted important experiments which involved exposing female guinea pig foetuses to testosterone. She showed for the first time that this can give rise to an increase of masculine sexual behavior in adulthood.^[18][19]

Danchakoff published many books as well as scientific papers, possibly her last publications being Le sexe; rôle de l'hérédité et des hormones dans sa réalisation in 1949 and Effects of cancer provoking chemical substances on gravid guinea pigs and their fruits in 1950.^[20][21][22]

Notes

References