UPB1

UPB1
Identifiers
Aliases UPB1, BUP1, beta-ureidopropionase 1
External IDs MGI: 2143535 HomoloGene: 9471 GeneCards: UPB1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

51733

103149

Ensembl

ENSG00000100024

ENSMUSG00000033427

UniProt

Q9UBR1

Q8VC97

RefSeq (mRNA)

NM_016327

NM_133995

RefSeq (protein)

NP_057411.1

NP_598756.1

Location (UCSC) Chr 22: 24.49 – 24.53 Mb Chr 10: 75.41 – 75.44 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-ureidopropionase is an enzyme that in humans is encoded by the UPB1 gene.[3][4]

This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article

|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Vreken P, van Kuilenburg AB, Hamajima N, Meinsma R, van Lenthe H, Gohlich-Ratmann G, Assmann BE, Wevers RA, van Gennip AH (Dec 1999). "cDNA cloning, genomic structure and chromosomal localization of the human BUP-1 gene encoding beta-ureidopropionase". Biochim Biophys Acta. 1447 (2–3): 251–7. doi:10.1016/s0167-4781(99)00182-7. PMID 10542323.
  4. 1 2 "Entrez Gene: UPB1 ureidopropionase, beta".

Further reading


This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.