Toponomics

Toponomics is a discipline in systems biology, molecular cell biology, and histology.[1][2] It concerns the study of the toponome of organisms. The toponome is the spatial network code of proteins and other biomolecules in morphologically intact cells and tissues.[2][3] The terms toponome and toponomics were introduced by Walter Schubert in 2003[1] based on observations with imaging cycler microscopes (ICM). The term “toponome” is derived from the ancient Greek nouns “topos” (τόπος; place, position) and “nomos” (νόμος; law). Hence the term toponomics is descriptive term addressing the fact that the spatial network of biomolecules in cells follows topological rules enabling coordinated actions.[1] This spatial organization is directly revealed by imaging cycler microscopy with parameter- and dimension-unlimited functional resolution. The resulting toponome structures are hierarchically organized and can be described by a three symbol code.[1][3][4][5] Toponomics is the field of study that has at its goal to decode the complete toponome in health and disease (The human toponome project[6]) – the next big challenge in human biotechnology after having decoded the human genome.[6][7]

Citations

  1. 1 2 3 4 Schubert, W (2003). "Topological Proteomics, Toponomics, MELK-Technology.". Advances in Biochemical Engineering/Biotechnology. 83: 189–209. doi:10.1007/3-540-36459-5_8.
  2. 1 2 Schubert, W (2013). "Toponomics" in Dubitzky, Wolkenhauer, Cho, Yokota. Encyclopedia of Systems Biology. Springer New York. pp. 2191–2212. ISBN 978-1-4419-9862-0.
  3. 1 2 Schubert, Walter; Bonnekoh, Bernd; Pommer, Ansgar J; Philipsen, Lars; Böckelmann, Raik; Malykh, Yanina; Gollnick, Harald; Friedenberger, Manuela; Bode, Marcus; Dress, Andreas W M (1 October 2006). "Analyzing proteome topology and function by automated multidimensional fluorescence microscopy". Nature Biotechnology. 24 (10): 1270–1278. doi:10.1038/nbt1250.
  4. ↑ Schubert, Walter (June 2007). "A three-symbol code for organized proteomes based on cyclical imaging of protein locations". Cytometry Part A. 71A (6): 352–360. doi:10.1002/cyto.a.20281.
  5. ↑ Schubert, W. "Direct, spatial imaging of randomly large supermolecules by using parameter unlimited TIS imaging cycler microscopy." (PDF). International Microscopy Conference 2013. Retrieved 2013-09-23.
  6. 1 2 Cottingham, Katie (May 2008). "Human Toponome Project | Human Proteinpedia is open for (free) business". Journal of Proteome Research. 7 (5): 1806–1806. doi:10.1021/pr083701k.
  7. ↑ Abott, A (12 October 2006). ""Mapping togetherness" (research highlight referring to Schubert et al. 2006)". Nature. 443 (7112): 608–609. doi:10.1038/443608a.
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