Thymosin beta-4, Y-chromosomal

TMSB4Y

Identifiers

TMSB4Y, TB4Y, thymosin beta 4, Y-linked

External IDs

GeneCards: TMSB4Y

Gene ontology
Molecular function	• actin binding • actin monomer binding • protein binding
Cellular component	• cytoplasm • cytoskeleton • cytosol • nucleus
Biological process	• sequestering of actin monomers • regulation of actin polymerization or depolymerization • actin filament organization • osteoblast differentiation • regulation of cell migration
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


9087


n/a


ENSG00000154620


n/a


O14604


n/a

RefSeq (mRNA)


NM_004202


n/a

RefSeq (protein)


NP_004193.1


n/a

Location (UCSC)

Chr Y: 13.7 – 13.71 Mb

n/a

PubMed search

^[1]

n/a

View/Edit Human

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene.^[2]^[3]

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.^[4]

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein.^[3]

References

↑ "Human PubMed Reference:".
↑ Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. doi:10.1126/science.278.5338.675. PMID 9381176.
1 2 "Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked".
↑ http://www.ncbi.nlm.nih.gov/protein/NP_004193

Further reading

Yu FX, Lin SC, Morrison-Bogorad M, et al. (1993). "Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins". J. Biol. Chem. 268 (1): 502–9. PMID 8416954.
Li X, Zimmerman A, Copeland NG, et al. (1997). "The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization". Genomics. 32 (3): 388–94. doi:10.1006/geno.1996.0133. PMID 8838802.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Torikai H, Akatsuka Y, Miyazaki M, et al. (2005). "A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene". J. Immunol. 173 (11): 7046–54. doi:10.4049/jimmunol.173.11.7046. PMID 15557202.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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