Thiomorpholine-carboxylate dehydrogenase

The 3 substrates of this enzyme are thiomorpholine 3-carboxylate, NAD⁺, and NADP⁺, whereas its 4 products are 3,4-dehydro-thiomorpholine-3-carboxylate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase. Other names in common use include ketimine reductase, and ketimine-reducing enzyme.

CRYM, a taxon-specific crystallin protein that also binds thyroid hormones has thiomorpholine-carboxylate dehydrogenase activity.

References

Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D (1988). "Purification and characterization of a ketimine-reducing enzyme". Eur. J. Biochem. 173 (3): 689–94. doi:10.1111/j.1432-1033.1988.tb14053.x. PMID 3371353.

Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase

1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

1.5.99	Sarcosine dehydrogenase Cytokinin dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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