Talastine

Talastine
Clinical data
ATC code R06AB07 (WHO)
Identifiers
CAS Number 16188-61-7 YesY
PubChem (CID) 65624
ChemSpider 59065 YesY
UNII 49AB2PA48B YesY
Chemical and physical data
Formula C19H21N3O
Molar mass 307.39 g/mol
3D model (Jmol) Interactive image
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Talastine (trade name Ahanon) is an antihistamine.[1]

Synthesis

The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with diethylaminoethyl chloride.[2]

References

  1. Richter, G.; Kühn, E. (1990). "Talastine (Ahanon) as a cause of allergic drug exanthema". Dermatologische Monatschrift. 176 (2–3): 111–113. PMID 1973126.
  2. Engelbrecht et al., DE 1046625; eidem, U.S. Patent 3,017,411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben).


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