Tagatose-bisphosphate aldolase

tagatose-bisphosphate aldolase
Identifiers
EC number 4.1.2.40
CAS number 39433-95-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a tagatose-bisphosphate aldolase (EC 4.1.2.40) is an enzyme that catalyzes the chemical reaction

D-tagatose 1,6-bisphosphate glycerone phosphate + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one substrate, D-tagatose 1,6-bisphosphate, and two products, glycerone phosphate and D-glyceraldehyde 3-phosphate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming). This enzyme is also called D-tagatose-1,6-bisphosphate triosephosphate lyase. This enzyme participates in galactose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GVF.

References

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