TRAK2

TRAK2
Identifiers
Aliases TRAK2, ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98, trafficking kinesin protein 2
External IDs MGI: 1918077 HomoloGene: 22861 GeneCards: TRAK2
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

66008

70827

Ensembl

ENSG00000115993

ENSMUSG00000026028

UniProt

O60296

n/a

RefSeq (mRNA)

NM_015049

NM_172406

RefSeq (protein)

NP_055864.2

n/a

Location (UCSC) Chr 2: 201.38 – 201.45 Mb Chr 1: 58.9 – 58.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.[3][4][5]

Interactions

TRAK2 has been shown to interact with Kir2.1[6] and GABRB2.[7]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
  4. ↑ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Feb 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nature Genetics. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
  5. ↑ "Entrez Gene: TRAK2 trafficking protein, kinesin binding 2".
  6. ↑ Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.
  7. ↑ Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.

Further reading

  • Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581. 
  • Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520. 
  • Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717. 
  • Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". The Journal of Biological Chemistry. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728. 
  • Brickley K, Smith MJ, Beck M, Stephenson FA (Apr 2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". The Journal of Biological Chemistry. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324. 
  • Fransson S, Ruusala A, Aspenström P (Jun 2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochemical and Biophysical Research Communications. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562. 
  • Smith MJ, Pozo K, Brickley K, Stephenson FA (Sep 2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". The Journal of Biological Chemistry. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241. 
  • Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905. 


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