TAOK1

TAOK1

Identifiers

TAOK1, KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAO kinase 1

External IDs

MGI: 1914490 HomoloGene: 27041 GeneCards: TAOK1

Gene ontology
Molecular function	• transferase activity • protein kinase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • signal transducer, downstream of receptor, with serine/threonine kinase activity
Cellular component	• cytoplasm • cytosol • extracellular exosome
Biological process	• phosphorylation • execution phase of apoptosis • positive regulation of JNK cascade • G2 DNA damage checkpoint • cellular response to DNA damage stimulus • protein phosphorylation • spindle checkpoint • regulation of cytoskeleton organization • DNA repair • positive regulation of stress-activated MAPK cascade • apoptotic process • signal transduction by protein phosphorylation • sister chromatid cohesion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


57551


216965


ENSG00000160551


ENSMUSG00000017291


Q7L7X3


Q5F2E8

RefSeq (mRNA)


NM_020791 NM_025142


NM_144825

RefSeq (protein)


NP_065842.1 NP_079418.1


NP_659074.2

Location (UCSC)

Chr 17: 29.39 – 29.55 Mb

Chr 11: 77.53 – 77.61 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
↑ Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM (Sep 2003). "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1". EMBO J. 22 (19): 5090–101. doi:10.1093/emboj/cdg447. PMC 204455. PMID 14517247.
↑ "Entrez Gene: TAOK1 TAO kinase 1".

Further reading

Hutchison M, Berman KS, Cobb MH (1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". J. Biol. Chem. 273 (44): 28625–32. doi:10.1074/jbc.273.44.28625. PMID 9786855.
Chen Z, Hutchison M, Cobb MH (1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". J. Biol. Chem. 274 (40): 28803–7. doi:10.1074/jbc.274.40.28803. PMID 10497253.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Zihni C, Mitsopoulos C, Tavares IA, et al. (2006). "Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1". J. Biol. Chem. 281 (11): 7317–23. doi:10.1074/jbc.M513769200. PMID 16407310.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Raman M, Earnest S, Zhang K, et al. (2007). "TAO kinases mediate activation of p38 in response to DNA damage". EMBO J. 26 (8): 2005–14. doi:10.1038/sj.emboj.7601668. PMC 1852793. PMID 17396146.
Draviam VM, Stegmeier F, Nalepa G, et al. (2007). "A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling". Nat. Cell Biol. 9 (5): 556–64. doi:10.1038/ncb1569. PMID 17417629.

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