TAF2

TAF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FUR
Identifiers
Aliases	TAF2, CIF150, MRT40, TAF2B, TAFII150, TATA-box binding protein associated factor 2
External IDs	MGI: 2443028 HomoloGene: 31137 GeneCards: TAF2
Gene ontology Molecular function • sequence-specific DNA binding • zinc ion binding • chromatin binding • transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly • protein binding • transcription regulatory region DNA binding • metallopeptidase activity • RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly Cellular component • transcription factor TFTC complex • transcription factor TFIID complex • nucleoplasm • nucleus Biological process • regulation of transcription, DNA-templated • response to organic cyclic compound • transcription elongation from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • proteolysis • G2/M transition of mitotic cell cycle • transcription initiation from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • RNA polymerase II transcriptional preinitiation complex assembly • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6873	319944
Ensembl	ENSG00000064313	ENSMUSG00000037343
UniProt	Q6P1X5	Q8C176
RefSeq (mRNA)	NM_003184	NM_001081288
RefSeq (protein)	NP_003175.1	n/a
Location (UCSC)	Chr 8: 119.73 – 119.83 Mb	Chr 15: 55.02 – 55.07 Mb
PubMed search	[1]	[2]
Wikidata

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.^[3][4][5]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.^[5]

References

Further reading

External links

• TAF2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)