T-cell lymphoma invasion and metastasis-inducing protein 1

TIAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P, 4NXP, 4NXQ, 4NXR
Identifiers
Aliases	TIAM1, T-cell lymphoma invasion and metastasis-inducing protein 1
External IDs	MGI: 103306 HomoloGene: 2443 GeneCards: TIAM1
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rac GTPase binding • signal transducer activity, downstream of receptor • microtubule binding • receptor tyrosine kinase binding • Ras GTPase binding • kinase binding • protein binding • Rho guanyl-nucleotide exchange factor activity • lipid binding • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • membrane • cell-cell junction • cell-cell contact zone • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • dendritic spine • axonal growth cone • synapse • main axon • ruffle membrane • cell junction • neuronal cell body • somatodendritic compartment • microtubule • nucleus Biological process • protein localization to membrane • apoptotic process • regulation of insulin secretion involved in cellular response to glucose stimulus • intracellular signal transduction • activation of GTPase activity • positive regulation of JUN kinase activity • ephrin receptor signaling pathway • cardiac muscle hypertrophy • regulation of non-canonical Wnt signaling pathway • positive regulation of axonogenesis • neuron projection extension • Wnt signaling pathway, planar cell polarity pathway • regulation of dopaminergic neuron differentiation • regulation of ERK1 and ERK2 cascade • positive regulation of neuron projection development • positive regulation of apoptotic process • positive regulation of Schwann cell chemotaxis • positive regulation of protein binding • cell-matrix adhesion • Rac protein signal transduction • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • cell migration • positive regulation of dendritic spine morphogenesis • signal transduction • response to cocaine • positive regulation of cell proliferation • positive regulation of cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7074	21844
Ensembl	ENSG00000156299	ENSMUSG00000002489
UniProt	Q13009	Q60610
RefSeq (mRNA)	NM_003253	NM_001145886 NM_001145887 NM_009384
RefSeq (protein)	NP_003244.2	n/a
Location (UCSC)	Chr 21: 31.12 – 31.56 Mb	Chr 16: 89.79 – 89.98 Mb
PubMed search	[1]	[2]
Wikidata

T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene.^[3][4][5]

Structure

TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.

Function

TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Clinical significance

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Interactions

T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1,^[6] Myc,^[7] RAC1^[8][9] and PPP1R9B.^[10]

Tiam1 interacts also with para-cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.^[11]

References

Further reading

External links

• UMich Orientation of Proteins in Membranes protein/pdbid-1foe - Calculated spatial position of TIAM1-RAC2 complex in membrane

PDB gallery
1foe: CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1  2d8i: Solution structure of the PDZ domain of T-cell lymphoma invasion and metastasis 1 varian