Synaptotagmins
Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B.
There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins.
Members
- Synaptotagmin 1 (SYT1)
- Synaptotagmin 2 (SYT2)
- Synaptotagmin 3 (SYT3)
- Synaptotagmin 4 (SYT4)
- Synaptotagmin 5 (SYT5)
- Synaptotagmin 6 (SYT6)
- Synaptotagmin 7 (SYT7)
- Synaptotagmin 8 (SYT8)
- Synaptotagmin 9 (SYT9)
- Synaptotagmin 10 (SYT10)
External links
- UMich Orientation of Proteins in Membranes families/superfamily-47 - Orientations of C2 domains in the lipid bilayer
- Synaptotagmins at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 3/14/2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.