SprX small RNA

In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics.

References

  1. ↑ Bohn, Chantal; Rigoulay, Candice; Chabelskaya, Svetlana; Sharma, Cynthia M.; Marchais, Antonin; Skorski, Patricia; Borezée-Durant, Elise; Barbet, Romain; Jacquet, Eric (2010-10-01). "Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism". Nucleic Acids Research. 38 (19): 6620–6636. doi:10.1093/nar/gkq462. ISSN 1362-4962. PMID 20511587.
  2. ↑ Eyraud, Alex; Tattevin, Pierre; Chabelskaya, Svetlana; Felden, Brice (2014-04-01). "A small RNA controls a protein regulator involved in antibiotic resistance in Staphylococcus aureus". Nucleic Acids Research. 42 (8): 4892–4905. doi:10.1093/nar/gku149. ISSN 1362-4962. PMID 24557948.


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