Sodium-proton antiporter
Na+/H+ antiporter 1 | |||||||||
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Identifiers | |||||||||
Symbol | Na_H_antiport_1 | ||||||||
Pfam | PF06965 | ||||||||
InterPro | IPR004670 | ||||||||
TCDB | 2.A.36 | ||||||||
OPM superfamily | 346 | ||||||||
OPM protein | 1zcd | ||||||||
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Sodium/proton antiporters are essential secondary-active transporters for sodium and pH homeostasis.[1] In human cells, defects in sodium/proton antiport result in heart or kidney failure and other serious diseases.
Families
There are several families of sodium/proton antiporters that facilitate the exchange of sodium ions with protons across the lipid membrane. Some of them include:[2]
- TC# 2.A.33 - Na+:H+ Antiporter (NhaA) Family
- TC# 2.A.34 - Na+:H+ Antiporter (NhaB) Family
- TC# 2.A.35 - Na+:H+ Antiporter (NhaC) Family
- TC# 2.A.36 - Monovalent Cation:Proton Antiporter-1 (CPA1) Family
- TC# 2.A.37 - Monovalent Cation:Proton Antiporter-2 (CPA2) Family
- TC# 2.A.62 - Na+:H+ Antiporter (NhaD) Family
- TC# 2.A.63 - Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family
- TC# 2.A.111 - Na+:H+ Antiporter (NhaE) Family
References
This article incorporates text from the public domain Pfam and InterPro IPR004670
- ↑ Padan, Etana; Landau, Meytal (2016). "Chapter 12. Sodium-Proton (Na+/H+) Antiporters:Properties and Roles in Health and Disease". In Astrid, Sigel; Helmut, Sigel; Roland K.O., Sigel. The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. 16. Springer. pp. 391–458. doi:10.1007/978-4-319-21756-7_12.
- ↑ "TCDB » HOME". Transporter Classification Database. Retrieved 2016-03-14.
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