Gerontology

Gerontology (from the Greek γέρων, geron, "old man" and -λογία, -logia, "study of"; coined by Ilya Ilyich Mechnikov in 1903) is the study of the social, cultural, psychological, cognitive, and biological aspects of aging.[1] It is distinguished from geriatrics, which is the branch of medicine that specializes in the treatment of existing disease in older adults. Gerontologists include researchers and practitioners in the fields of biology, nursing, medicine, criminology, dentistry, social work, physical and occupational therapy, psychology, psychiatry, sociology, economics, political science, architecture, geography, pharmacy, public health, housing, and anthropology.[2]

Gerontology encompasses the following:

The multidisciplinary nature of gerontology means that there are a number of sub-fields, as well as associated fields such as physiology, anthropology, social work, public health, psychology and sociology that overlap with gerontology.

History

In the medieval Islamic world, several physicians wrote on issues related to Gerontology. Avicenna's The Canon of Medicine (1025) offered instruction for the care of the aged, including diet and remedies for problems including constipation.[3] Arabic physician Ibn Al-Jazzar Al-Qayrawani (Algizar, c. 898–980) wrote on the aches and conditions of the elderly (Ammar 1998, p. 4).[4] His scholarly work covers sleep disorders, forgetfulness, how to strengthen memory,[5][6] and causes of mortality[7] Ishaq ibn Hunayn (died 910) also wrote works on the treatments for forgetfulness (U.S. National Library of Medicine, 1994).[8]

While the number of aged humans, and the life expectancy, tended to increase in every century since the 14th, society tended to consider caring for an elderly relative as a family issue. It was not until the coming of the Industrial Revolution that ideas shifted in favor of a societal care-system.

Some early pioneers, such as Michel Eugène Chevreul, who himself lived to be 102, believed that aging itself should be a science to be studied. Élie Metchnikoff coined the term "gerontology" c. 1903[9]

It was not until the 1940s that pioneers like James Birren began organizing gerontology into its own field. Recognizing that there were experts in many fields all dealing with the older population, it became apparent that a group like the Gerontological Society of America (founded in 1945) was needed. Two decades later, James Birren was appointed as the founding director of the first academic research center devoted exclusively to the study of aging, the Ethel Percy Andrus Gerontology Center.[10] The Baltimore Longitudinal Studies of Aging began in 1958 in order to study physiological changes in healthy middle-aged and older men living in the community by testing them every two years on numerous physiological parameters.[2] In 1967, the University of South Florida[11] and the University of North Texas (formerly North Texas State University) received Older Americans Act training grants from the U.S. Administration on Aging to launch the nation's first degree programs in gerontology, at the master's level. In 1975, the University of Southern California's Leonard Davis School of Gerontology,[12] became the country's first school of gerontology within a university and, later, offered the first PhD in Gerontology degree.

Gerontological Education has flourished in the United States since 1967 and degrees at all academic levels are now offered by a number of colleges and universities.[13] One of the pioneering gerontologists, Robert Neil Butler, pushed for care and respect of the elderly. Several university-based centers on aging have been founded such as the Duke University Center on Aging, the University of Georgia Institute of Gerontology, the Center of Aging at the University of Chicago,[14] and the Stanford Center on Longevity.[2] Currently, PhD programs in gerontology are available at Miami University,[15] the University of Kansas,[16] University of Kentucky,[17] University of Maryland Baltimore,[18] University of Massachusetts Boston,[19] and the University of Southern California.[20]

Aging demographics

The world is forecast to undergo rapid population aging in the next several decades. In 1900, there were 3.1 million people aged 65 years and older living in the United States. However, this population continued to grow throughout the 20th century and reached 31.2, 35, and 40.3 million people in 1990, 2000, and 2010, respectively. Notably, in the United States and across the world, the "baby boomer" generation began to turn 65 in 2011. Recently, the population aged 65 years and older has grown at a faster rate than the total population in the United States. The total population increased by 9.7%, from 281.4 million to 308.7 million, between 2000 and 2010. However, the population aged 65 years and older increased by 15.1% during the same period.[21] It has been estimated that 25% of the population in the United States and Canada will be aged 65 years and older by 2025. Moreover, by 2050, it is predicted that, for the first time in United States history, the number of individuals aged 60 years and older will be greater than the number of children aged 0 to 14 years.[22] Those aged 85 years and older (oldest-old) are projected to increase from 5.3 million to 21 million by 2050.[23] Adults aged 85–89 years constituted the greatest segment of the oldest-old in 1990, 2000, and 2010. However, the largest percentage point increase among the oldest-old occurred in the 90- to 94-year-old age group, which increased from 25.0% in 1990 to 26.4% in 2010.[21]

With the rapid growth of the aging population, social work education and training specialized in older adults and practitioners interested in working with older adults are increasingly in demand.[24][25]

Gender differences with age

There has been a considerable disparity between the number of men and women in the older population in the United States. In both 2000 and 2010, women outnumbered men in the older population at every single year of age (e.g., 65 to 100 years and over). The sex ratio, which is a measure used to indicate the balance of males to females in a population, is calculated by taking the number of males divided by the number of females, and multiplying by 100. Therefore, the sex ratio is the number of males per 100 females. In 2010, there were 90.5 males per 100 females in the 65-year-old population. However, this represented an increase from 1990 when there were 82.7 males per 100 females, and from 2000 when the sex ratio was 88.1. Although the gender gap between men and women has narrowed, women continue to have a greater life expectancy and lower mortality rates at older ages relative to men. For example, the Census 2010 reported that there were approximately twice as many women as men living in the United States at 89 years of age (361,309 versus 176,689, respectively).[21]

Geographic distribution of older adults

The number and percentage of older adults living in the United States vary across the four different regions (Northeast, Midwest, West, and South) defined by the United States census. In 2010, the South contained the greatest number of people aged 65 years and older and 85 years and older. However, proportionately, the Northeast contains the largest percentage of adults aged 65 years and older (14.1%), followed by the Midwest (13.5%), the South (13.0%), and the West (11.9%). Relative to the Census 2000, all geographic regions demonstrated positive growth in the population of adults aged 65 years and older and 85 years and older. The most rapid growth in the population of adults aged 65 years and older was evident in the West (23.5%), which showed an increase from 6.9 million in 2000 to 8.5 million in 2010. Likewise, in the population aged 85 years and older, the West (42.8%) also showed the fastest growth and increased from 806,000 in 2000 to 1.2 million in 2010. It is worth highlighting that Rhode Island was the only state that experienced a reduction in the number of people aged 65 years and older, and declined from 152,402 in 2000 to 151,881 in 2010. Conversely, all states exhibited an increase in the population of adults aged 85 years and older from 2000 to 2010.[21]

Biogerontology

The hand of an older adult

Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. It involves interdisciplinary research on biological aging's causes, effects, and mechanisms. Conservative biogerontologists such as Leonard Hayflick have predicted that the human life expectancy will peak at about 92 years old,[26] while others such as James Vaupel have predicted that in industrialized countries life expectancies will reach 100 for children born after the year 2000.[27] and some surveyed biogerontologists have predicted life expectancies of two or more centuries.[28] with Aubrey de Grey offering the "tentative timeframe" that with adequate funding of research to develop interventions in aging such as Strategies for Engineered Negligible Senescence, "we have a 50/50 chance of developing technology within about 25 to 30 years from now that will, under reasonable assumptions about the rate of subsequent improvements in that technology, allow us to stop people from dying of aging at any age," leading to life expectancies of 1,000 years.[29]

Biomedical gerontology, also known as experimental gerontology and life extension, is a sub-discipline of biogerontology that endeavors to slow, prevent, and even reverse aging in both humans and animals. By preventing senescent changes in animals,[30] these therapies would prevent the onset of age-related disease and frailty, extending both average and maximum lifespan. Most "life extensionists" believe the human life span can be increased within the next century, if not sooner. Biogerontologists vary in the degree to which they focus on the study of the aging process as a means of mitigating the diseases of aging or extending lifespan, although most agree that extension of lifespan will necessarily flow from reductions in age-related disease and frailty, although some argue that maximum life span cannot be altered or that it is undesirable to try.

In contrast with biogerontology, geriatrics studies the treatment of disease in aging people. Both fields are considered by many scientists to be the most important medical frontiers in aging research.

Biological theories of aging

Theories of aging are numerous and no one theory has been accepted. There is a wide spectrum of the types of theories for the causes of aging with programmed theories on one extreme and error theories on the other. Regardless of the theory, a commonality is that as humans age, functions of the body decline.[22]

Wear and tear

Wear and tear theories of aging suggest that as an individual ages, body parts such as cells and organs wear out from continued use. Wearing of the body can be attributable to internal or external causes that eventually lead to an accumulation of insults which surpasses the capacity for repair. Due to these internal and external insults, cells lose their ability to regenerate, which ultimately leads to mechanical and chemical exhaustion. Some insults include chemicals in the air, food, or smoke. Other insults may be things such as viruses, trauma, free radicals, cross-linking, and high body temperature.[22]

Genetic

Genetic theories of aging propose that aging is programmed within each individual's genes. According to this theory, genes dictate cellular longevity. Programmed cell death, or apoptosis, is determined by a "biological clock" via genetic information in the nucleus of the cell. Genes responsible for apoptosis provide an explanation for cell death, but are less applicable to death of an entire organism. An increase in cellular apoptosis may correlate to aging, but is not a 'cause of death'. Environmental factors and genetic mutations can influence gene expression and accelerate aging. More recently epigenetics have been explored as a contributing factor. The epigenetic clock, which objectively measures the biological age of cells and tissues, may become useful for testing different biological aging theories.[31]

General imbalance

General imbalance theories of aging suggest that body systems, such as the endocrine, nervous, and immune systems, gradually decline and ultimately fail to function. The rate of failure varies system by system.[22]

Accumulation

Accumulation theories of aging suggest that aging is bodily decline that results from an accumulation of elements. Elements can be foreign and introduced to the body from the environment. Other elements can be the natural result of cell metabolism.[22] An example of an accumulation theory is the Free Radical Theory of Aging. According to this theory, byproducts of regular cell metabolism called free radicals interact with cellular components such as the cell membrane and DNA and cause irreversible damage.[32]

The free radical theory of aging

The idea that free radicals are toxic agents was first proposed by Rebeca Gerschman and colleagues.[33] In 1956, Denham Harman proposed the free-radical theory of aging and even demonstrated that free radical reactions contribute to the degradation of biological systems.[34] Oxidative damage of many types accumulate with age, such as oxidative stress that oxygen-free radicals,[35] because the free radical theory of aging argues that aging results from the damage generated by reactive oxygen species (ROS).[36] ROS are small, highly reactive, oxygen-containing molecules that can damage a complex of cellular components such as fat, proteins, or from DNA, they are naturally generated in small amounts during the body's metabolic reactions. These conditions become more common as we age, including diseases related to aging, such as dementia, cancer and heart disease.

The DNA damage theory of aging

DNA damage has been one of the many causes in diseases related to aging. The stability of the genome is defined by the cells machinery of repair, damage tolerance, and checkpoint pathways that counteracts DNA damage. One hypothesis proposed by Gioacchino Failla in 1958[37] is that damage accumulation to the DNA causes aging. The hypothesis was developed soon by physicist Leó Szilárd.[38] This theory has changed over the years as new research has discovered new types of DNA damage and mutations, and several theories of aging argue that DNA damage with or without mutations causes aging.[39]

Social gerontology

Social gerontology is a multi-disciplinary sub-field that specializes in studying or working with older adults. Social gerontologists may have degrees or training in social work, nursing, psychology, sociology, demography, public health, or other social science disciplines. Social gerontologists are responsible for educating, researching, and advancing the broader causes of older people.

Because issues of life span and life extension need numbers to quantify them, there is an overlap with demography. Those who study the demography of the human life span differ from those who study the social demographics of aging.

Social theories of aging

Several theories of aging are developed to observed the aging process of older adults in society as well as how these processes are interpreted by men and women as they age.[40]

Activity theory

Activity theory was developed and elaborated by Cavan, Havighurst, and Albrecht. According to this theory, older adults' self-concept depends on social interactions. In order for older adults to maintain morale in old age, substitutions must be made for lost roles. Examples of lost roles include retirement from a job or loss of a spouse.[40]

Activity is preferable to inactivity because it facilitates well-being on multiple levels. Because of improved general health and prosperity in the older population, remaining active is more feasible now than when this theory was first proposed by Havighurst nearly six decades ago. The activity theory is applicable for a stable, post-industrial society, which offers its older members many opportunities for meaningful participation.Weakness: Some aging persons cannot maintain a middle-aged lifestyle, due to functional limitations, lack of income, or lack of a desire to do so. Many older adults lack the resources to maintain active roles in society. On the flip side, some elders may insist on continuing activities in late life that pose a danger to themselves and others, such as driving at night with low visual acuity or doing maintenance work to the house while climbing with severely arthritic knees. In doing so, they are denying their limitations and engaging in unsafe behaviors.[41]

Disengagement theory

Disengagement theory was developed by Cumming and Henry. According to this theory, older adults and society engage in a mutual separation from each other. An example of mutual separation is retirement from the workforce. A key assumption of this theory is that older adults lose "ego-energy" and become increasingly self-absorbed. Additionally, disengagement leads to higher morale maintenance than if older adults try to maintain social involvement. This theory is heavily criticized for having an escape clause - namely, that older adults who remain engaged in society are unsuccessful adjusters to old age.[40]

Gradual withdrawal from society and relationships preserves social equilibrium and promotes self-reflection for elders who are freed from societal roles. It furnishes an orderly means for the transfer of knowledge, capital, and power from the older generation to the young. It makes it possible for society to continue functioning after valuable older members die.

Continuity theory

Continuity theory is an elusive concept. On the one hand, to exhibit continuity can mean to remain the same, to be uniform, homogeneous, unchanging, even humdrum. This static view of continuity is not very applicable to human aging. On the other hand, a dynamic view of continuity starts with the idea of a basic structure which persists over time, but it allows for a variety of changes to occur within the context provided by the basic structure. The basic structure is coherent: It has an orderly or logical relation of parts that is recognizably unique and that allows us to differentiate that structure from others. With the introduction of the concept of time, ideas such as direction, sequence, character development, and story line enter into the concept of continuity as it is applied to the evolution of a human being. In this theory, a dynamic concept of continuity is developed and applied to the issue of adaptation to normal aging.[42]

A central premise of continuity theory is that, in making adaptive choices, middle-aged and older adults attempt to preserve and maintain existing internal and external structures and that they prefer to accomplish this objective by using continuity (i.e., applying familiar strategies in familiar arenas of life). In middle and later life, adults are drawn by the weight of past experience to use continuity as a primary adaptive strategy for dealing with changes associated with normal aging. To the extent that change builds upon, and has links to, the person's past, change is a part of continuity. As a result of both their own perceptions and pressures from the social environment, individuals who are adapting to normal aging are both predisposed and motivated toward inner psychological continuity as well as outward continuity of social behavior and circumstances.[43]

Continuity theory views both internal and external continuity as robust adaptive strategies that are supported by both individual preference and social sanctions. Continuity theory consists of general adaptive principles that people who are normally aging could be expected to follow, explanations of how these principles work, and a specification of general areas of life in which these principles could be expected to apply. Accordingly, continuity theory has enormous potential as a general theory of adaptation to individual aging.[44]

Age stratification theory

According to this theory, older adults born during different time periods form cohorts that define "age strata". There are two differences among strata: chronological age and historical experience. This theory makes two arguments. 1. Age is a mechanism for regulating behavior and as a result determines access to positions of power. 2. Birth cohorts play an influential role in the process of social change.[40]

Life course theory

According to this theory, which stems from the Life Course Perspective (Bengston and Allen, 1993),[45] aging occurs from birth to death. Aging involves social, psychological, and biological processes. Additionally, aging experiences are shaped by cohort and period effects.[40]

Also reflecting the life course focus, consider the implications for how societies might function when age-based norms vanish—a consequence of the deinstitutionalization of the life course— and suggest that these implications pose new challenges for theorizing aging and the life course in postindustrial societies. Dramatic reductions in mortality, morbidity, and fertility over the past several decades have so shaken up the organization of the life course and the nature of educational, work, family, and leisure experiences that it is now possible for individuals to become old in new ways. The configurations and content of other life stages are being altered as well, especially for women. In consequence, theories of age and aging will need to be reconceptualized.[46]

Cumulative advantage/disadvantage theory

According to this theory, which was developed beginning in the 1960s by Derek Price and Robert Merton and elaborated on by several researchers such as Dale Dannefer,[47] inequalities have a tendency to become more pronounced throughout the aging process. A paradigm of this theory can be expressed in the adage "the rich get richer and the poor get poorer". Advantages and disadvantages in early life stages have a profound effect throughout the life span. However, advantages and disadvantages in middle adulthood have a direct influence on economic and health status in later life.[40]

Environmental gerontology

Environmental gerontology[48][49][50] is a specialization within gerontology that seeks to develop an understanding, means of analysis, opportunities to modify, and interventions that optimize the relationship between the aging person and their physical and social environment, utilizing interdisciplinary perspectives and approaches to attain these goals.

The field first began to emerge in the 1930s during the first studies on behavioral and social gerontology, and were associated with deterministic explanations of the relationship between aging and environment from genetic parameters and biological. In the 1970s and 1980s, theories of different researchers, as Kurt Lewin (living space model as a function of the person and the environment) and, mainly, M. Powell Lawton (1923–2001) (ecological adaptation model), based on the influence of the interactions between the older person and their environment (adaptation – ambient pressure), confirm the importance of the physical and social environment (objective and subjective) in the understanding of the aging population and the possibility of improving the quality of life in old age. Environmental Gerontology[51] seeks to understand the socio-spatial implications of aging and its complex relationship with the environment, from analysis at different scales: micro scales (home and family) and macro scales (neighborhood, city, region), to enable social and environmental planning and policies that enable better aging. Among the main contributions of the discipline are the contributions to aging in place (wherever that place may be) and that older people prefer to age in their immediate environment where aspects such as spatial experience and place attachment are important for understanding the process.[52]

The most famous environmental gerontologist remains M. Powell Lawton (1923–2001).

See also

References

  1. ↑ Confluence. "Gerontology/Geriatrics Definitions". www.aghe.org. Retrieved 2016-11-25.
  2. 1 2 3 Hooyman, N.R.; Kiyak, H.A. (2011). Social gerontology: A multidisciplinary perspective (9th ed.). Boston: Pearson Education. ISBN 0205763138.
  3. ↑ Howell, Trevor H. (1987). "Avicenna and His Regimen of Old Age". Age and Ageing. 16 (1): 58–59. doi:10.1093/ageing/16.1.58. PMID 3551552.
  4. ↑ Ammar, S (1998). "Vesalius" (PDF). Official Journal of the International Society for the History of Medicine. 4: 48.
  5. ↑ "Ibn al-Jazzār, Abū Ja'far Ahmad ibn Ibrāhīm ibn Abī Khālid (d. 979/369)". Islamic Medical Manuscripts. U.S. National Library of Medicine. Retrieved 24 September 2013.
  6. ↑ [Geritt Bos, Ibn al-Jazzar, Risala fi l-isyan (Treatise on forgetfulness), London, 1995 ]
  7. ↑ Al Jazzar
  8. ↑ "Specialized literature". Islamic culture and medical arts. U.S. National Library of Medicine. Retrieved 24 September 2013.
  9. ↑ Online Etymology Dictionary
  10. ↑ "Ethel Percy Andrus". USC Davis School of Gerontology. Retrieved 2013-06-25.
  11. ↑ "Welcome to the University of South Florida". University of South Florida. Retrieved 2013-06-25.
  12. ↑ "Leonard Davis". USC Davis School of Gerontology. Retrieved 2013-06-25.
  13. ↑ Haley, William E.; Zelinski, Elizabeth (2007). "Progress and challenges in graduate education in gerontology: The U.S. experience". Gerontology & Geriatrics Education. 27 (3): 11–26. doi:10.1300/J021v27n03_02.
  14. ↑ "Center on the Demography and Economics of Aging Center on Aging Center on the Demography and Economics of Aging". Spc.uchicago.edu. Retrieved 2013-06-25.
  15. ↑ "PhD in Social Gerontology | Scripps Gerontology Center". Scripps.muohio.edu. Retrieved 2013-06-25.
  16. ↑ "Master of Arts and Doctor of Philosophy in Gerontology". The University of Kansas. Retrieved 2013-06-25.
  17. ↑ "Graduate Center for Gerontology". University of Kentucky. 2013-04-14. Retrieved 2013-06-25.
  18. ↑ "Application Procedures". University of Maryland. Retrieved 2013-06-25.
  19. ↑ "PhD - University of Massachusetts Boston". Umb.edu. Retrieved 2013-06-25.
  20. ↑ "Graduate Degrees Catalogue 2013/14". University of Southern California. 2013-05-25. Retrieved 2013-06-25.
  21. 1 2 3 4 Carrie A. Werner (2010). "The Older Population: 2010" (PDF). 2010 Census Briefs. U.S. Census Bureau. C2010BR-09.
  22. 1 2 3 4 5 Taylor, Albert W.; Johnson, Michel J. (2008). Physiology of Exercise and Healthy Aging. Human Kinetics. ISBN 978-0-7360-5838-4.
  23. ↑ "Population". 2008 Older Americans : Key indicators of Well-Being. 2008.
  24. ↑ "Institute for Geriatric Social Work". Boston University.
  25. ↑ "Geriatric Social Work Initiative".
  26. ↑ Watts G (June 2011). "Leonard Hayflick and the limits of ageing". Lancet. 377 (9783): 2075. doi:10.1016/S0140-6736(11)60908-2. PMID 21684371.
  27. ↑ Christensen, L; Doblhammer, K; Rau, G; Vaupel, JW (2009). "Ageing populations: the challenges ahead". Lancet. 374 (9696): 1196–1208. doi:10.1016/s0140-6736(09)61460-4. PMC 2810516Freely accessible. PMID 19801098.
  28. ↑ Richel, Theo (December 2003). "Will human life expectancy quadruple in the next hundred years? Sixty gerontologists say public debate on life extension is necessary". J Anti-Aging Med. 6 (4): 309–314. doi:10.1089/109454503323028902. PMID 15142432.
  29. ↑ de Grey, Aubrey D. N. J.; Rae, Michael (October 14, 2008). Ending Aging. St. Martin's Griffin. p. 15. ISBN 0312367074.
  30. ↑ Pourmemar E, Majdi A, Haramshahi M, Talebi M, Karimi P, Sadigh-Eteghad S (2017). "Intranasal Cerebrolysin Attenuates Learning and Memory Impairments in D-galactose-Induced Senescence in Mice". Experimental Gerontology. 87: 16–22. doi:10.1016/j.exger.2016.11.011. PMID 27894939.
  31. ↑ Horvath S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14 (10): R115. doi:10.1186/gb-2013-14-10-r115. PMC 4015143Freely accessible. PMID 24138928.
  32. ↑ Schneider, EL (1992). "Biological theories of aging". Generations. 16 (4): 7.
  33. ↑ Fenn, Rebecca; Gilbert, DL, Nye, SW, Dwyer, P, and Fenn WO; Nye, Sylvanus W.; Dwyer, Peter; Fenn, Wallace O. (7 May 1954). "Oxygen poisoning and x-irradiation: a mechanism in common". Science. 119 (3097): 623–626. Bibcode:1954Sci...119..623G. doi:10.1126/science.119.3097.623. PMID 13156638.
  34. ↑ Harman, D (November 1981). "The aging process". Proc. Natl. Acad. Sci. U.S.A. 78 (11): 7124–7128. doi:10.1073/pnas.78.11.7124. PMC 349208Freely accessible. PMID 6947277.
  35. ↑ Hagen, Bruce N; MK Shigenaga; TM Hagen (September 1993). "Oxidants, antioxidants, and the degenerative diseases of aging". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7915–7922. Bibcode:1993PNAS...90.7915A. doi:10.1073/pnas.90.17.7915. PMC 47258Freely accessible. PMID 8367443.
  36. ↑ Beckman, KB; Ames BN (April 1998). "The free radial theory of aging matures". Physiol Rev. 78 (2): 547–581. PMID 9562038.
  37. ↑ Failla, G (30 September 1958). "The aging process and cancerogenesis". Annals of the New York Academy of Sciences. 71 (6): 1124–1140. Bibcode:1958NYASA..71.1124F. doi:10.1111/j.1749-6632.1958.tb46828.x. PMID 13583876.
  38. ↑ Szilard, Leo (January 1959). "On the nature of the aging process". Proc. Natl. Acad. Sci. U.S.A. 45 (1): 30–45. doi:10.1073/pnas.45.1.30. PMC 222509Freely accessible. PMID 16590351.
  39. ↑ Freitas, AA; de Magalhaes, JP (Jul–Oct 2011). "A review and appraisal of the DNA damage theory of ageing". Mutat Res. 728 (1–2): 12–22. doi:10.1016/j.mrrev.2011.05.001. PMID 21600302.
  40. 1 2 3 4 5 6 Phillipson, C.; Baars, J. (2007). "Ch. 4: Social theory and social ageing". In Bond, J.; Peace, S. M.; Dittmann-Kohli, F.; Westerhof, G. Ageing in Society (3rd ed.). SAGE. pp. 68–84. ISBN 978-1-4129-0020-1.
  41. ↑ VickyRN. (August 2, '09). Theories of Aging (Part 3) - Sociological Theories. Retrieved Friday, April 20, 2012, from http://allnurses-breakroom.com/showthread.php?t=412760
  42. ↑ Blalock, H.M. (1982). Conceptualization and measurement in the social sciences. Beverly Hills: Sage. ISBN 0803918046.
  43. ↑ Hage, J. (1972). Techniques and problems of theory construction in sociology. New York: Wiley Interscience. ISBN 0471338605.
  44. ↑ Kaplan, Abraham (1964). The Conduct of Inquiry: Methodology for Behavioral Science. Transaction Publishers. ISBN 978-0-7658-0448-8.
  45. ↑ Life Course Theory-Historical Development, Key Principles and Concepts, Selected Research Applications:http://family.jrank.org/pages/1074/Life-Course-Theory.html
  46. ↑ Rowe, J.W.; Kahn, R.L. (1998). Successful aging. New York: Pantheon. ISBN 0375400451.
    Webster, N. (2003). Webster’s new American dictionary. New York: HarperCollins.
  47. ↑ Dannefer D (November 2003). "Cumulative advantage/disadvantage and the life course: cross-fertilizing age and social science theory". J Gerontol B Psychol Sci Soc Sci. 58 (6): S327–37. doi:10.1093/geronb/58.6.S327. PMID 14614120.
  48. ↑ Sánchez-González, Diego; Rodríguez-Rodríguez, Vicente (2016). Environmental Gerontology in Europe and Latin America. Policies and perspectives on environment and aging. New York: Springer Publishing Company. p. 284. ISBN 978-3-319-21418-4.
  49. ↑ Rowles, Graham D.; Bernard, Miriam (2013). Environmental Gerontology: Making Meaningful Places in Old Age. New York: Springer Publishing Company. p. 320. ISBN 978-0826108135.
  50. ↑ Scheidt, Rick J.; Schwarz, Benyamin (2013). Environmental Gerontology. What Now?. New York: Routledge. p. 338. ISBN 978-0-415-62616-3.
  51. ↑ Wahl, H-W.; Scheidt, R.J.; Windley, P.G. (2004). Annual Review of Gerontology and Geriatrics. Focus on Aging context: Socio-Physical Environments. New York: Springer Publishing Company. p. 384. ISBN 978-0826117342.
  52. ↑ Andrews, GJ.; Phillips, DR. (2005). Ageing and Place: Perspectives, Policy, Practice. London: Routledge. p. 272. ISBN 978-0415481656.
This article is issued from Wikipedia - version of the 12/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.