Small nuclear ribonucleoprotein polypeptide E

SNRPE

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR

Identifiers

Aliases

SNRPE, B-raf, HYPT11, SME, Sm-E, Small nuclear ribonucleoprotein polypeptide E, snRNP-E

External IDs

MGI: 3650419 HomoloGene: 136765 GeneCards: SNRPE

Gene ontology
Molecular function	• protein binding • RNA binding
Cellular component	• cytoplasm • SMN-Sm protein complex • cytosol • catalytic step 2 spliceosome • U4/U6 x U5 tri-snRNP complex • U5 snRNP • U12-type spliceosomal complex • intracellular ribonucleoprotein complex • U2 snRNP • nucleoplasm • U1 snRNP • methylosome • U7 snRNP • precatalytic spliceosome • small nuclear ribonucleoprotein complex • pICln-Sm protein complex • telomerase holoenzyme complex • spliceosomal complex • U4 snRNP • extracellular exosome • nucleus
Biological process	• hair cycle • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • spliceosomal snRNP assembly • spliceosomal complex assembly • histone mRNA metabolic process • nuclear import • RNA splicing
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6635


102632439

Ensembl


ENSG00000182004


n/a

UniProt


P62304


n/a

RefSeq (mRNA)


NM_001304464 NM_003094 NM_001328637 NM_001328638


n/a

RefSeq (protein)


NP_001291393.1 NP_003085.1


n/a

Location (UCSC)

Chr 1: 203.86 – 203.87 Mb

n/a

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.^[3]^[4]^[5]

Interactions

Small nuclear ribonucleoprotein polypeptide E has been shown to interact with DDX20^[6] and Small nuclear ribonucleoprotein polypeptide F.^[7]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Fautsch MP, Wieben ED (January 1992). "Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins". J Biol Chem. 266 (34): 23288–95. PMID 1835977.
↑ Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I, Heinzmann C, Wieben ED (September 1990). "Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43". Genomics. 7 (4): 503–8. doi:10.1016/0888-7543(90)90192-W. PMID 2143747.
↑ "Entrez Gene: SNRPE small nuclear ribonucleoprotein polypeptide E".
↑ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. UNITED STATES. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333.
↑ Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. UNITED STATES. 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867.

Sauterer RA, Goyal A, Zieve GW (1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts.". J. Biol. Chem. 265 (2): 1048–58. PMID 1688550.
Stanford DR, Rohleder A, Neiswanger K, Wieben ED (1987). "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene.". J. Biol. Chem. 262 (21): 9931–4. PMID 2440864.
Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles.". J. Biol. Chem. 264 (10): 5776–83. PMID 2522439.
Stanford DR, Perry CA, Holicky EL, et al. (1988). "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins.". J. Biol. Chem. 263 (33): 17772–9. PMID 2972723.
Stanford DR, Kehl M, Perry CA, et al. (1989). "The complete primary structure of the human snRNP E protein.". Nucleic Acids Res. 16 (22): 10593–605. doi:10.1093/nar/16.22.10593. PMC 338926. PMID 2974536.
Woppmann A, Rinke J, Lührmann R (1989). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ.". Nucleic Acids Res. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
Kamiyama T, Aoki N, Yuasa Y (1993). "B-raf oncogene: activation by rearrangements and assignment to human chromosome 7.". Jpn. J. Cancer Res. 84 (3): 250–6. doi:10.1111/j.1349-7006.1993.tb02864.x. PMID 8098025.
Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core.". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins.". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.

RNA-binding protein: Ribonucleoproteins

snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200

hnRNP	A0 C L R

Other transcription	Telomerase

Translation	Ribosome

Vault ribonucleoprotein particles	Major vault protein

Other	Signal recognition particle

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Small nuclear ribonucleoprotein polypeptide E

Interactions

References

Further reading