Small multidrug resistance protein

Small Multidrug Resistance protein
Identifiers
Symbol Multi_Drug_Res
Pfam PF00893
InterPro IPR000390
SCOP 1s7b
SUPERFAMILY 1s7b
TCDB 2.A.7
OPM protein 2f2m

Small multidrug resistance protein is a family of integral membrane proteins which confer drug resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. An example is Escherichia coli mvrC P23895 which prevents the incorporation of methyl viologen into cells[1] and is involved in ethidium bromide efflux.[2]

References

  1. Morimyo M, Hongo E, Hama-inaba H, Machida I (1992). "Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity". Nucleic Acids Res. 20 (12): 3159–3165. doi:10.1093/nar/20.12.3159. PMC 312453Freely accessible. PMID 1320256.
  2. Purewal AS (1991). "Nucleotide sequence of the ethidium efflux gene from Escherichia coli". FEMS Microbiol. Lett. 66 (2): 229–231. doi:10.1111/j.1574-6968.1991.tb04870.x. PMID 1936950.

This article incorporates text from the public domain Pfam and InterPro IPR000390


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