Sean O'Brien
Sean O'Brien may refer to:
- Seán O'Brien (Gaelic footballer), Gaelic footballer with Nemo Rangers
- Seán O'Brien (rugby player) (born 1987), Irish rugby union player
- Sean O'Brien (rugby player born 1994), Irish rugby player
- Sean O'Brien (writer) (born 1952), British writer
- Sean O'Brien (musician), bassist and original member of Boston rock band Come
- Seán O'Brien (hurler) (1926–?), Irish hurler
- Sean O'Brien (ice hockey) (born 1972), American former ice hockey left winger
- Sean O'Brien (Ohio politician), Democratic member of the Ohio House of Representatives
- Sean O'Brien (windsurfer) (born 1984), Australian windsurfer
- Sean C. O'Brien, co-discoverer of buckminsterfullerene
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