SYCP3

SYCP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases SYCP3, COR1, SCP3, SPGF4, RPRGL4, synaptonemal complex protein 3
External IDs MGI: 109542 HomoloGene: 7964 GeneCards: SYCP3
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

50511

20962

Ensembl

ENSG00000139351

ENSMUSG00000020059

UniProt

Q8IZU3

P70281

RefSeq (mRNA)

NM_001177948
NM_001177949
NM_153694

NM_011517

RefSeq (protein)

NP_001171419.1
NP_001171420.1
NP_710161.1

NP_035647.2

Location (UCSC) Chr 12: 101.73 – 101.74 Mb Chr 10: 88.46 – 88.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene.[3][4][5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Martinez-Garay I, Jablonka S, Sutajova M, Steuernagel P, Gal A, Kutsche K (September 2002). "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region". Genomics. 80 (3): 259–67. doi:10.1006/geno.2002.6834. PMID 12213195.
  4. ↑ Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD (June 2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Research. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879Freely accessible. PMID 10854409.
  5. ↑ "Entrez Gene: SYCP3 synaptonemal complex protein 3".

Further reading

  • Yuan L, Liu JG, Zhao J, Brundell E, Daneholt B, Höög C (January 2000). "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility". Molecular Cell. 5 (1): 73–83. doi:10.1016/S1097-2765(00)80404-9. PMID 10678170. 
  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163Freely accessible. PMID 11591653. 
  • Lee J, Iwai T, Yokota T, Yamashita M (July 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". Journal of Cell Science. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374. 
  • Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ (November 2003). "Azoospermia in patients heterozygous for a mutation in SYCP3". Lancet. 362 (9397): 1714–9. doi:10.1016/S0140-6736(03)14845-3. PMID 14643120. 
  • de Boer P, Giele M, Lock MT, de Rooij DG, Giltay J, Hochstenbach R, te Velde ER (2004). "Kinetics of meiosis in azoospermic males: a joint histological and cytological approach". Cytogenetic and Genome Research. 105 (1): 36–46. doi:10.1159/000078007. PMID 15218256. 
  • Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (October 2005). "SYCP3 mutations are uncommon in patients with azoospermia". Fertility and Sterility. 84 (4): 1019–20. doi:10.1016/j.fertnstert.2005.04.033. PMID 16213863. 
  • Aarabi M, Modarressi MH, Soltanghoraee H, Behjati R, Amirjannati N, Akhondi MM (August 2006). "Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia". Fertility and Sterility. 86 (2): 325–31. doi:10.1016/j.fertnstert.2005.12.070. PMID 16824523. 
  • Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434. 
  • Martínez J, Bonache S, Carvajal A, Bassas L, Larriba S (October 2007). "Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest". Fertility and Sterility. 88 (4): 988–9. doi:10.1016/j.fertnstert.2006.11.163. PMID 17434513. 
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