STK24

STK24
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases STK24, HEL-S-95, MST3, MST3B, STE20, STK3, serine/threonine kinase 24
External IDs MGI: 2385007 HomoloGene: 20793 GeneCards: STK24
Genetically Related Diseases
Alzheimer's disease[1]
Targeted by Drug
bosutinib[2]
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

8428

223255

Ensembl

ENSG00000102572

ENSMUSG00000063410

UniProt

Q9Y6E0
Q5JV99

Q99KH8

RefSeq (mRNA)

NM_001032296
NM_001286649
NM_003576

NM_145465

RefSeq (protein)

NP_001027467.2
NP_003567.2

NP_663440.1

Location (UCSC) Chr 13: 98.45 – 98.58 Mb Chr 14: 121.29 – 121.38 Mb
PubMed search [3] [4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene.[5][6][7]

The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000).[supplied by OMIM][7]

Interactions

STK24 has been shown to interact with PDCD10,[8][9][10] TRAF3IP3,[10] STRN3,[9][10] MOBKL3,[9][10] STRN,[9][10] SLMAP,[9][10] PPP2R1A,[9][10] CTTNBP2NL,[10] FAM40A[9][10] and STRN4.[9][10]

References

  1. "Diseases that are genetically associated with STK24 view/edit references on wikidata".
  2. "Drugs that physically interact with Serine/threonine-protein kinase 24 view/edit references on wikidata".
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Schinkmann K, Blenis J (Dec 1997). "Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements". J Biol Chem. 272 (45): 28695–703. doi:10.1074/jbc.272.45.28695. PMID 9353338.
  6. Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G (Feb 2000). "Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase". J Biol Chem. 275 (4): 2513–9. doi:10.1074/jbc.275.4.2513. PMID 10644707.
  7. 1 2 "Entrez Gene: STK24 serine/threonine kinase 24 (STE20 homolog, yeast)".
  8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  9. 1 2 3 4 5 6 7 8 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. England. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931.
  10. 1 2 3 4 5 6 7 8 9 10 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. United States. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004Freely accessible. PMID 18782753.

Further reading


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