SOAT1

Not to be confused with Acetyl-Coenzyme A acetyltransferase.
SOAT1
Identifiers
Aliases SOAT1, ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, sterol O-acyltransferase 1
External IDs MGI: 104665 HomoloGene: 2333 GeneCards: SOAT1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

6646

20652

Ensembl

ENSG00000057252

ENSMUSG00000026600

UniProt

P35610

Q61263

RefSeq (mRNA)

NM_001252511
NM_001252512
NM_003101

NM_009230

RefSeq (protein)

NP_001239440.1
NP_001239441.1
NP_003092.4

NP_033256.2

Location (UCSC) Chr 1: 179.29 – 179.36 Mb Chr 1: 156.42 – 156.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, also known as SOAT1, is an enzyme that in humans is encoded by the SOAT1 gene.[3]

Function

Acyl-coenzyme A:cholesterol acyltransferase (EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article

|px|alt=Statin Pathway edit]]

Statin Pathway edit

  1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See also

References

Further reading


This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.