Monocarboxylate transporter 3
Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.[3] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.
Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.
See also
References
Further reading
- Yoon H, Donoso LA, Philp NJ (1999). "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics. 60 (3): 366–70. doi:10.1006/geno.1999.5926. PMID 10493836.
- Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
- Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
- Cori CF (1981). "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul. 18: 377–87. PMID 7273846.
- Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.
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- proton coupled metal ion transporter
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- human Na+-sulfate/carboxylate cotransporter
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- proton oligopeptide cotransporter
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- monocarboxylate transporter
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- Na+-dependent ascorbic acid transporter
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- multifunctional anion exchanger
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- Na+-coupled nucleoside transport (SLC28A1
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- facilitative nucleoside transporter
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- type II Na+-phosphate cotransporter
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- nucleoside-sugar transporter
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- SLC35E1
- SLC35E2
- SLC35E3
- SLC35E4
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- proton-coupled amino-acid transporter
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- sugar-phosphate/phosphate exchanger
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- System A & N, sodium-coupled neutral amino-acid transporter
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- basolateral iron transporter
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- Na+-independent, system-L like amino-acid transporter
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- Putative sugar transporter
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see also solute carrier disorders |