Monocarboxylate transporter 2

SLC16A7
Identifiers
Aliases SLC16A7, MCT2, solute carrier family 16 member 7
External IDs MGI: 1330284 HomoloGene: 20990 GeneCards: SLC16A7
Orthologs
Species Human Mouse
Entrez

9194

20503

Ensembl

ENSG00000118596

ENSMUSG00000020102

UniProt

O60669

O70451

RefSeq (mRNA)

NM_001270622
NM_001270623
NM_004731

NM_011391

RefSeq (protein)

NP_001257551.1
NP_001257552.1
NP_004722.2

NP_035521.1

Location (UCSC) Chr 12: 59.6 – 59.79 Mb Chr 10: 125.23 – 125.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.[3] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722.

Further reading


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