SENP6

SENP6
Identifiers
Aliases SENP6, SSP1, SUSP1, SUMO1/sentrin specific peptidase 6
External IDs MGI: 1922075 HomoloGene: 9196 GeneCards: SENP6
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

26054

215351

Ensembl

ENSG00000112701

ENSMUSG00000034252

UniProt

Q9GZR1

Q6P7W0

RefSeq (mRNA)

NM_001100409
NM_001304792
NM_015571

NM_146003
NM_001311110

RefSeq (protein)

NP_001093879.1
NP_001291721.1
NP_056386.2

NP_001298039.1
NP_666115.2

Location (UCSC) Chr 6: 75.6 – 75.72 Mb Chr 9: 80.07 – 80.14 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.[3]

Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins

See also

References

Further reading

  • Mikolajczyk J; Drag M; Békés M; Cao JT; Ronai Z; Salvesen GS. (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783. 
  • Drag M; Mikolajczyk J; Krishnakumar IM; Huang Z; Salvesen GS. (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063. 


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