SECISBP2

SECISBP2
Identifiers
Aliases SECISBP2, SBP2, SECIS binding protein 2
External IDs MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

79048

75420

Ensembl

ENSG00000187742

ENSMUSG00000035139

UniProt

Q96T21

n/a

RefSeq (mRNA)

NM_001282688
NM_001282689
NM_001282690
NM_024077

NM_029279
NM_001308448

RefSeq (protein)

NP_001269617.1
NP_001269618.1
NP_076982.3

n/a

Location (UCSC) Chr 9: 89.32 – 89.36 Mb Chr 13: 51.65 – 51.68 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.[3][4]

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.[4]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.[4]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Wiemann S; Weil B; Wellenreuther R; Gassenhuber J; Glassl S; Ansorge W; Bocher M; Blocker H; Bauersachs S; Blum H; Lauber J; Dusterhoft A; Beyer A; Kohrer K; Strack N; Mewes HW; Ottenwalder B; Obermaier B; Tampe J; Heubner D; Wambutt R; Korn B; Klein M; Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072Freely accessible. PMID 11230166.
  4. 1 2 3 "Entrez Gene: SECISBP2 SECIS binding protein 2".

Further reading


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