Rs1799913
| SNP: Rs1799913 | ||
|---|---|---|
| Name(s) | A779C | |
| Gene | TPH1 | |
| Chromosome | 11 | |
| Region | Intron 7 | |
| External databases | ||
| Ensembl | Human SNPView | |
| dbSNP | 1799913 | |
| HapMap | 1799913 | |
| SNPedia | 1799913 | |
| HgenetInfoDB | 1799913 | |
| SzGene | Meta-analysis | Overview |
In genetics, rs1799913, also called A779C, is a gene variation—a single nucleotide polymorphism (SNP)— in the TPH1 gene. It is located in intron 7.[1]
The SNP association with schizophrenia has been examined in several studies, though as of 2007 with no definitive conclusion.[2]
One study has found that the SNP may be associated with heroin addiction.[3]
A218C (rs1800532) is another SNP in the same intron in the same gene.[1]
References
- 1 2 D. A. Nielsen, G. L. Jenkins, K. M. Stefanisko, K. K. Jefferson & D. Goldman (April 1997). "Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7". Brain Research. Molecular Brain Research. 45 (1): 145–148. doi:10.1016/S0169-328X(96)00304-X. PMID 9105682.
- ↑ P. G. Sand (November 2007). "Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia". Human Genetics. 122 (3–4): 409–411. doi:10.1007/s00439-007-0383-6. PMID 17653577.
- ↑ David A. Nielsen, Sandra Barral, Dmitri Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek (March 2008). "TPH2 and TPH1: association of variants and interactions with heroin addiction". Behavior Genetics. 38 (2): 133–130. doi:10.1007/s10519-007-9187-7. PMID 18181017.
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