Rho kinase inhibitor

Rho kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK). Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular benefits of statin therapy. Furthermore, ROCK inhibitors may have clinical applications for anti-erectile dysfunction, antihypertension, and tumor metastasis inhibition.[1]

Examples

Chemical structure of fasudil

References

  1. James K. Liao; et al. (Jul 2007). "Rho Kinase (ROCK) Inhibitors". J Cardiovasc Pharmacol. 50 (1): 17–24. doi:10.1097/FJC.0b013e318070d1bd.
  2. "information of different kinds of ROCK inhibitor". selleckchemicals.
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