Retinyl acetate
Names | |
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IUPAC name
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate | |
Other names
Retinol acetate; Vitamin A acetate; Vitamin A1 acetate; Acetylretinol; all-trans-Retinol acetate; all-trans-Retinyl acetate; all-trans-Vitamin A acetate; | |
Identifiers | |
127-47-9 | |
3D model (Jmol) | Interactive image |
ChemSpider | 553599 |
ECHA InfoCard | 100.004.405 |
PubChem | 638034 |
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Properties | |
C22H32O2 | |
Molar mass | 328.50 g·mol−1 |
Melting point | 57 to 58 °C (135 to 136 °F; 330 to 331 K)[1] |
Hazards | |
R-phrases | R38-R63[1] |
S-phrases | S36/37[1] |
NFPA 704 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.[2][3]
In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods with vitamin A.[4][5]
Teratogenicity
World Health Organization recommendation on Maternal Supplementation During Pregnancy states that "health benefits are expected for the mother and her developing fetus with little risk of detriment to either, from a daily supplement not exceeding 10,000IU [preformed] vitamin A (3000mcg RE) at any time during pregnancy." Preformed Vitamin A refers to retinyl palmitate and retinyl acetate. [6]
References
- 1 2 3 Retinyl acetate from Sigma-Aldrich
- ↑ Moon, Richard C.; Grubbs, Clinton J.; Sporn, Michael B.; Goodman, Dawn G. (1977). "Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea". Nature. 267 (5612): 620–1. doi:10.1038/267620a0. PMID 876383.
- ↑ Retinyl acetate, National Cancer Institute Drug Dictionary
- ↑ Select Committee on GRAS Substances (SCOGS) Opinion: Vitamin A, United States Food and Drug Administration
- ↑ 21 C.F.R. 184.1930
- ↑ http://whqlibdoc.who.int/hq/1998/WHO_NUT_98.4_eng.pdf
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