Plasmanylethanolamine desaturase
| plasmanylethanolamine desaturase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.99.19 | ||||||||
| CAS number | 39391-13-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a plasmanylethanolamine desaturase (EC 1.14.99.19) is an enzyme that catalyzes the chemical reaction
- O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
The 3 substrates of this enzyme are O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine, an electron acceptor AH2, and O2, whereas its 3 products are O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, the reduction product A, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxy gen oxidoreductase. Other names in common use include alkylacylglycerophosphoethanolamine desaturase, alkylacylglycero-phosphorylethanolamine dehydrogenase, dehydrogenase, alkyl-acylglycerophosphorylethanolamine, 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase, and 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase. This enzyme participates in ether lipid metabolism. It has 3 cofactors: ATP, Manganese, and Magnesium.
References
- Paltauf F, Holasek A (1973). "Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine". J. Biol. Chem. 248 (5): 1609–15. PMID 4144394.
- Wykle RL, Blank ML, Malone B, Snyder F (1972). "Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine". J. Biol. Chem. 247 (17): 5442–7. PMID 4403444.