Phytoene desaturase (lycopene-forming)

Phytoene desaturase (lycopene-forming)
Identifiers
EC number 1.3.99.31
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Phytoene desaturase (lycopene-forming) (EC 1.3.99.31, 4-step phytoene desaturase, four-step phytoene desaturase, phytoene desaturase (ambiguous), CrtI (ambiguous)) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (lycopene-forming).[1] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 4 acceptor all-trans-lycopene + 4 reduced acceptor (overall reaction)
(1a) 15-cis-phytoene + acceptor all-trans-phytofluene + reduced acceptor
(1b) all-trans-phytofluene + acceptor all-trans-zeta-carotene + reduced acceptor
(1c) all-trans-zeta-carotene + acceptor all-trans-neurosporene + reduced acceptor:
(1d) all-trans-neurosporene + acceptor all-trans-lycopene + reduced acceptor

This enzyme is involved in carotenoid biosynthesis.

References

  1. Fraser, P.D.; Misawa, N.; Linden, H.; Yamano, S.; Kobayashi, K.; Sandmann, G. (1992). "Expression in Escherichia coli, purification, and reactivation of the recombinant Erwinia uredovora phytoene desaturase". J. Biol. Chem. 267: 19891–19895. PMID 1400305.
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